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- Publications
- Influence
Biomimetic Synthesis of Natural and “Unnatural” Lignans by Oxidative Coupling of Caffeic Esters
- Carmelo Daquino, A. Rescifina, C. Spatafora, C. Tringali
- Chemistry
- 1 December 2009
The metal-mediated oxidative coupling of caffeic acid esters has been employed in the biomimetic synthesis of dimeric lignans and neolignans. Phenethyl and methyl caffeate esters were used as… Expand
Recent advances in small organic molecules as DNA intercalating agents: synthesis, activity, and modeling.
- A. Rescifina, Chiara Zagni, M. G. Varrica, V. Pistarà, A. Corsaro
- Chemistry, Medicine
- European journal of medicinal chemistry
- 3 March 2014
The interaction of small molecules with DNA plays an essential role in many biological processes. As DNA is often the target for majority of anticancer and antibiotic drugs, study about the… Expand
Putative Inhibitors of SARS-CoV-2 Main Protease from A Library of Marine Natural Products: A Virtual Screening and Molecular Modeling Study
- Davide Gentile, Vincenzo Patamia, A. Scala, M. Sciortino, A. Piperno, A. Rescifina
- Biology, Medicine
- Marine drugs
- 1 April 2020
The current emergency due to the worldwide spread of the COVID-19 caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a great concern for global public health. Already… Expand
Production of filmable medium-chain-length polyhydroxyalkanoates produced from glycerol by Pseudomonas mediterranea.
- F. Pappalardo, M. Fragalà, +4 authors A. Rescifina
- Chemistry, Medicine
- International journal of biological…
- 1 April 2014
Glycerol is an effective carbon source for the production of scl- and mcl-polyhydroxyalkanoates (PHAs) by Pseudomonas spp. P. mediterranea 9.1 (CFBP 5447) synthesizes an amorphous mcl-PHA when grown… Expand
The Search for Potent, Small‐Molecule HDACIs in Cancer Treatment: A Decade After Vorinostat
- Chiara Zagni, Giuseppe Floresta, G. Monciino, A. Rescifina
- Medicine
- Medicinal research reviews
- 1 November 2017
Histone deacetylases (HDACs) play a crucial role in the remodeling of chromatin, and are involved in the epigenetic regulation of gene expression. In the last decade, inhibition of HDACs came out as… Expand
Development of a Sigma‐2 Receptor affinity filter through a Monte Carlo based QSAR analysis
- A. Rescifina, Giuseppe Floresta, +5 authors E. Amata
- Chemistry, Medicine
- European journal of pharmaceutical sciences…
- 30 August 2017
Abstract For the first time in sigma‐2 (&sgr;2) receptor field, a quantitative structure–activity relationship (QSAR) model has been built using pKi values of the whole set of known selective &sgr;2… Expand
Sigma-2 receptor ligands QSAR model dataset
- A. Rescifina, Giuseppe Floresta, +5 authors E. Amata
- Chemistry, Medicine
- Data in brief
- 16 June 2017
The data have been obtained from the Sigma-2 Receptor Selective Ligands Database (S2RSLDB) and refined according to the QSAR requirements. These data provide information about a set of 548 Sigma-2… Expand
Histone methyltransferase inhibitors: novel epigenetic agents for cancer treatment.
- C. Zagni, U. Chiacchio, A. Rescifina
- Medicine
- Current medicinal chemistry
- 2013
Epigenetics is defined as heritable changes in gene activity and expression that occur without alteration in DNA sequence. The gene transcription is strictly correlated to chromatin structure, which… Expand
Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents.
- Maria Dichiara, O. Prezzavento, +4 authors E. Amata
- Medicine, Chemistry
- European journal of medicinal chemistry
- 15 December 2017
In the search of novel strategies for the treatment of cancer, photodynamic therapy (PDT) has emerged as an effective, safe for repeated use, and non-invasive method. This technique involves the use… Expand
Progress in the development of selective heme oxygenase-1 inhibitors and their potential therapeutic application.
- L. Salerno, Giuseppe Floresta, +5 authors V. Pittalà
- Chemistry, Medicine
- European journal of medicinal chemistry
- 1 April 2019
Heme oxygenases (HOs) are a family of enzymes involved in the selective catabolism of free circulating heme. While HO-2 is constitutively expressed, HO-1 is strongly overexpressed under stressful… Expand
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