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Constitutive expression of yeast phospholipid biosynthetic genes by variants of Ino2 activator defective for interaction with Opi1 repressor
TLDR
RID–AID interaction is confirmed as the crucial step of regulated expression of ICRE‐dependent genes in yeast phospholipid biosynthesis by identifying nine residues critical for Opi1‐dependent repression of Ino2 function. Expand
Development of two pentaplex systems with X-chromosomal STR loci and their allele frequencies in a northeast German population.
TLDR
The applicability and usefulness of the two PCR pentaplex approaches in paternity deficiency cases is demonstrated by a combined power of discrimination (PD(c)) for both females and males with PD(c)>0.999999. Expand
The problem of single parent/child paternity analysis--practical results involving 336 children and 348 unrelated men.
TLDR
The results underline the difficulties in motherless paternity cases using only STR analysis and advise great precaution in assigning verbal predicates such as "paternity proven" in those investigations. Expand
Comparative analysis of promoter regions containing binding sites of the heterodimeric transcription factor Ino2/Ino4 involved in yeast phospholipid biosynthesis
TLDR
The expression pattern of selected genes containing ICRE promoter motifs, as identified by in silico analysis, supports the view that identification of regulatory elements by a database search provides evidence for a specific pattern of gene expression. Expand
Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1
TLDR
It is shown that TCR-activation antagonizes two necessary TFs for foxp3 gene transcription, which are themselves regulated by phosphorylation, and suggests novel targets for stabilisation and less dangerous application of iTreg during devastating inflammation. Expand
Screening Assays for Epigenetic Targets Using Native Histones as Substrates
TLDR
The authors report about the setup and establishment of in vitro assays that use native core histones as substrates, enabling an assay environment that better resembles native conditions and establish two new antibody-based assays. Expand
[Paternity analysis in deficiency cases with related putative fathers: simulation of a deficiency analysis in 27 families].
TLDR
The results show that the calculation of high probabilities does not necessarily lead to the accurate conclusion of fatherhood and in many of the cases misleadingly the brother of the real father or another close relative would have been declared to be the biological father. Expand
Complementation of non-tumorigenicity of HPV18-positive cervical carcinoma cells involves differential mRNA expression of cellular genes including potential tumor suppressor genes on chromosome 11q13.
TLDR
Several as yet unknown cellular genes that play a role in cell differentiation, cell cycle progression, cell-cell communication, metastasis formation, angiogenesis, antigen presentation, and immune response are detected in tumorigenic HPV18-positive hybrid and parental HeLa cells. Expand
DXS6797 contains two STRs which can be easily haplotyped in both sexes
TLDR
The length of the entire double-labelled amplicon is measured and a Taq-I-digested aliquot is measured to infer, for both males and females, compound haplotypes consisting of DXS6797 I and DXS 6797 II repeat length, which has the potential to provide 42 DXs6797 haplotypes. Expand
PRMT1 promotes the tumor suppressor function of p14ARF and is indicative for pancreatic cancer prognosis
TLDR
The data reveal that PRMT1‐mediated arginine methylation is an important trigger for p14ARF’s stress‐induced tumor‐suppressive function. Expand
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