Phospholipidosis as a function of basicity, lipophilicity, and volume of distribution of compounds.
- U. Hanumegowda, G. Wenke, A. Regueiro-Ren, R. Yordanova, J. Corradi, S. Adams
- Biology, ChemistryChemical Research in Toxicology
- 31 March 2010
A model to predict PLD in vivo using the measures of basicity, lipophilicity, and volume of distribution is developed and improved concordance is demonstrated with this method.
Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.
- R. Gentles, Min Ding, J. Kadow
- Chemistry, BiologyJournal of Medicinal Chemistry
- 7 January 2014
Structural-activity relationship studies resulted in the optimization of the activity of members of a class of cyclopropyl-fused indolobenzazepine HCV NS5B polymerase inhibitors, and analogues exhibiting improved solubility and membrane permeability were shown to have notably enhanced pharmacokinetic profiles.
Synthesis and biological activity of novel epothilone aziridines.
- A. Regueiro-Ren, R. Borzilleri, G. Vite
- Chemistry, BiologyOrganic Letters
- 26 July 2001
The results indicate that the aziridine moiety is a viable isosteric replacement for the epoxide in the case of epothilones.
Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.
- A. Regueiro-Ren, Zheng Liu, I. Dicker
- BiologyACS Medicinal Chemistry Letters
- 22 April 2016
The design, synthesis, and preclinical characterization of a potent, orally active, second generation HIV-1 MI, BMS-955176, which is currently in Phase IIb clinical trials as part of a combination antiretroviral regimen is described.
SAR and pH stability of cyano-substituted epothilones.
- A. Regueiro-Ren, Kenneth J. Leavitt, G. Vite
- Chemistry, BiologyOrganic Letters
- 8 October 2002
[formula: see text] 3-Cyano epothilones 15-18 are the only examples of non-hydroxy C-3-substituted analogues. Their tubulin binding affinity and cytotoxicity provide meaningful structure-activity…
The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.
- Yan Chen, S. Sit, A. Regueiro-Ren
- Chemistry, BiologyBioorganic & Medicinal Chemistry Letters
- 15 May 2018
Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage
- B. Nowicka-Sans, Tricia L. Protack, I. Dicker
- BiologyAntimicrobial Agents and Chemotherapy
- 18 April 2016
BMS-955176 is a second-generation MI with potent in vitro anti-HIV-1 activity and a greatly improved preclinical profile compared to that of bevirimat, and time-of-addition and pseudotype reporter virus studies confirm a mechanism of action for the compound that occurs late in the virus replication cycle.
C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.
- Zheng Liu, Jacob J. Swidorski, A. Regueiro-Ren
- Chemistry, BiologyBioorganic & Medicinal Chemistry
- 15 April 2016
Core-modified sordaricin derivatives: synthesis and antifungal activity.
- A. Regueiro-Ren, Tina M. Carroll, Balu N Balasubramanian
- Chemistry, BiologyBioorganic & Medicinal Chemistry Letters
- 2 December 2002
Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors
- Zeyu Lin, Joseph L. Cantone, I. Dicker
- BiologyPLoS Pathogens
- 1 November 2016
HIV-1 maturation inhibitors (MIs) disrupt the final step in the HIV-1 protease-mediated cleavage of the Gag polyprotein between capsid p24 capsid (CA) and spacer peptide 1 (SP1), leading to the…
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