A. Redzicka

Publications18
h-index5
Citations142
Highly Influential Citations5
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Antinociceptive, anti-inflammatory and smooth muscle relaxant activities of the pyrrolo[3,4-d]pyridazinone derivatives: Possible mechanisms of action
The aim of this study was to evaluate the analgesic as well as anti-inflammatory activities of the new pyrrolo[3,4-d]pyridazinone derivatives. Moreover, the present study attempted to assess some of… Expand
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Derivatives of pyrrolo[3,4-d]pyridazinone, a new class of analgesic agents.
A series of N2-{2-[4-aryl(benzyl)-1-piperazinyl(piperidinyl)]ethyl}pyrrolo[3,4-d]pyridazinones 4 and related derivatives 5 were synthesized as potential analgesic agents. The structures of the new… Expand
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Synthesis and analgesic action of N-(substituted-ethyl)pyrrole-3,4-dicarboximides.
We prepared a series of new N-[2-(4-substitutedpiperazin-1-yl)ethyl]-1-(n-butyl or phenyl)-2,5-dimethyl-3,4-pyrroledicarboximides 3 and the related products 4 and 5, nine representatives of which… Expand
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  • 1
New derivatives of pyrrolo[3,4-d]pyridazinone and their anticancer effects.
Eighteen new derivatives of pyrrolo[3,4-d]pyridazinone modified at the pyrrole and pyridazine rings were synthesized and 12 of them were evaluated in vitro through anticancer screenings. The… Expand
  • 59
New Derivatives of Pyrrolo[3,4-d]pyridazinone and Their Anticancer Effects.
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COX-1/COX-2 inhibition activities and molecular docking study of newly designed and synthesized pyrrolo[3,4-c]pyrrole Mannich bases.
In the present paper we describe the biological activity of newly designed and synthesized series of pyrrolo[3,4-c]pyrrole Mannich bases (7a-n). The Mannich bases were obtained in good yields by… Expand
  • 2
Antitumor in vitro evaluation of certain derivatives of pyrido-1,2-thiazines.
We report an antitumor in vitro evaluation of a small series of 3-phenyl(methyl)pyrazolo[4, 3-c] pyrido [3,2-e]-1,2-thiazines 4 and the related 3-benzoyl (acetyl)-4-hydroxypyrido… Expand
  • 2
Derivatives of Pyrrolo[3,4-d]pyridazinone, a New Class of Analgesic Agents.
Novel pyrrolo[3,4-d]pyridazinones (III) and (VII) are tested as potential analgesic agents.
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Design, synthesis, biological evaluation and in silico studies of novel pyrrolo[3,4-d]pyridazinone derivatives withpromising anti-inflammatory and antioxidant activity.
Novel Mannich base analogues of pyrrolo[3,4-d]pyridazinone 7a,b-13a,b are designed and synthesized as potential anti-inflammatory agents. The title compounds are obtained via convenient one-pot… Expand
Mechanism of solvolysis of N-[2-(4-o-fluorophenylpiperazin-1-yl)ethyl]-2,5-dimethyl-1-phenylpyrrole-3,4-dicarboximide (PDI).
The stability of N-[2-(4-o-fluorophenylpiperazin-1-yl)ethyl]-2,5-dimethyl-1-phenylpyrrole-3,4-dicarboximide (PDI; a derivative with an analgesic activity) was studied in order to investigate its… Expand