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Induction of nitric oxide synthase in asthma
Nitric oxide (NO) is a mediator of vasodilatation and bronchodilatation synthesised from L-arginine by the enzyme NO synthase, which is either constitutive or induced by lipopolysaccharides and/or… Expand
Investigation and management of chronic cough using a probability-based algorithm
- J. Kastelik, I. Aziz, J. Ojoo, R. Thompson, A. Redington, A. Morice
- European Respiratory Journal
- 1 February 2005
Chronic cough is a common and distressing symptom. A novel algorithm has been developed for the management of chronic cough, in which an assessment of clinical probability of disease determines the… Expand
T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma.
- N. Krug, J. Madden, +6 authors P. Howarth
- American journal of respiratory cell and…
- 1 April 1996
Atopic asthma is characterized by bronchial mucosal inflammation, involving eosinophils, mast cells, and lymphocytes. It has been suggested that the development and maintenance of this allergic… Expand
Exhaled breath condensate pH and exhaled nitric oxide in allergic asthma and in cystic fibrosis
Background: It has been proposed that the pH of airway lining fluid may regulate the fractional exhaled concentration of nitric oxide (FeNO) in respiratory disease. Methods: FeNO, exhaled breath… Expand
Sex-related differences in cough reflex sensitivity in patients with chronic cough.
- J. Kastelik, R. H. Thompson, I. Aziz, J. Ojoo, A. Redington, A. Morice
- American journal of respiratory and critical care…
- 1 October 2002
Among patients attending specialist cough clinics there is an excess of females, but the reason for this sex difference is unknown. We tested the hypothesis that the sensitivity of the cough reflex… Expand
Modulation of nitric oxide pathways: therapeutic potential in asthma and chronic obstructive pulmonary disease.
- A. Redington
- European journal of pharmacology
- 8 March 2006
Nitric oxide (NO) is present in the exhaled breath of humans and other mammalian species. It is generated in the lower airways by enzymes of the nitric oxide synthase (NOS) family, although… Expand
Dendritic cells in normal and asthmatic airways: expression of the alpha subunit of the high affinity immunoglobulin E receptor (Fc epsilon RI -alpha).
- J. Tunon-de-lara, A. Redington, +4 authors S. Holgate
- Clinical and experimental allergy : journal of…
- 1 June 1996
BACKGROUND Immunoglobulin E (IgE) plays an important role in asthma, with total serum IgE levels closely related to both clinical expression of the disease and airway hyperresponsiveness. IgE binds… Expand
Airway fibrosis in asthma: mechanisms, consequences, and potential for therapeutic intervention.
- A. Redington
- Monaldi archives for chest disease = Archivio…
A distinctive feature of asthma is the presence of a fibrotic response characterized by excess extracellular matrix deposition and proliferation of myofibroblasts, in the airway wall. This review… Expand
Airway wall remodelling in asthma.
it is cartilaginous airways of <10mm and [10mm were con-apparent that airﬂow obstruction in asthma is often not sidered separately, the increase in wall area was found tocompletely reversible. A… Expand
Cytokine profiles of BAL T cells and T‐cell clones obtained from human asthmatic airways after local allergen challenge
Background: This study assessed the heterogeneity of cytokine expression in asthma before and after local allergen challenge.