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Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.
- P. ten Dijke, H. Yamashita, K. Miyazono
- Biology, ChemistryThe Journal of biological chemistry
- 24 June 1994
Results suggest thatALK-3 and ALK-6 are type I receptors for OP-1 and BMP-4; in addition, ALk-2 is a type I receptor shared by activin and OP- 1, but not by B MP-4.
Biochemical sequences in the transformation of normal fibroblasts in adolescent rats.
Coarse powders of acid-insoluble matrix of diaphysis and calvarial parietal bone rapidly and consistently transformed fibroblasts into masses of cartilage and bone containing hemopoietic marrow. The…
Identification of multiple active growth factors in basement membrane Matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components.
Role of morphogenetic proteins in skeletal tissue engineering and regeneration
- A. Reddi
- Biology, EngineeringNature Biotechnology
- 1 March 1998
Rules of tissue architecture elucidated in bone morphogenesis may provide insights into tissue engineering and be universally applicable for all organs/tissues, including bones and joints.
Characterization of Growth Factor-binding Structures in Heparin/Heparan Sulfate Using an Octasaccharide Library*
- Satoko Ashikari-Hada, H. Habuchi, Y. Kariya, N. Itoh, A. Reddi, K. Kimata
- Biology, ChemistryJournal of Biological Chemistry
- 26 March 2004
A library of octasaccharides is generated by semienzymatic methods by using recombinant HS 2-O-sulfotransferase and HS 6-O -sulfOTransferases to define specific structures required for binding to various heparin-binding proteins and may provide new reagents to specifically regulate bindings of the growth factors to HS.
Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation.
Observations demonstrate the dissociative extraction and successful biological reconstitution of bone inductive macromolecules in demineralized bone matrix.
Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development.
Morphogenesis and tissue engineering of bone and cartilage: inductive signals, stem cells, and biomimetic biomaterials.
- A. Reddi
- Biology, EngineeringTissue engineering
- 1 August 2000
The rules of architecture for tissue engineering are an imitation of the laws of developmental biology and morphogenesis, and thus may be universal for all tissues, including bones and joints.