Share This Author
Disentangling Genetic Variation for Resistance and Tolerance to Infectious Diseases in Animals
Using rodent malaria in laboratory mice as a model system and the statistical framework developed by plant-pathogen biologists, genetic variation for tolerance is demonstrated, as measured by the extent to which anemia and weight loss increased with increasing parasite burden.
Heterogeneities in macroparasite infections : patterns and processes.
Decomposing health: tolerance and resistance to parasites in animals
- L. Råberg, A. Graham, A. Read
- BiologyPhilosophical Transactions of the Royal Society B…
- 12 January 2009
The statistical framework for analysis of tolerance developed in plant science and how this can be applied to animals is described and evidence of genetic and environmental variation for tolerance in animals is reviewed, and studies indicating which mechanisms could contribute to this variation are reviewed.
The Ecology of Genetically Diverse Infections
Microparasite infections often consist of genetically distinct clonal lineages that influence disease severity, epidemiology, and evolution, and much of the theory in this area is based on assumptions contradicted by the available data.
Imperfect vaccines and the evolution of pathogen virulence
It is shown that vaccines designed to reduce pathogen growth rate and/or toxicity diminish selection against virulent pathogens, which leads to higher levels of intrinsic virulence and hence to more severe disease in unvaccinated individuals.
The evolution of virulence
Why is there variation in the virulence of infectious diseases? Virulence can have substantial effects on the genetic contribution of both host and pathogen to future generations. Understanding it…
The relationship between abundance and body size in British birds
It is shown that phylogenetic relatedness might be an important indicator of the structure of the relationship between body size and abundance, and those tribes that do not share recent common ancestry with other British birds are most likely to show a positive relationship across their constituent species.
EVOLUTIONARY ECOLOGY OF PLANT ADAPTATION TO SERPENTINE SOILS
■ Abstract Plant adaptation to serpentine soil has been a topic of study for many decades, yet investigation of the genetic component of this adaptation has only recently begun. We review the…
Maternal Transfer of Strain-Specific Immunity in an Invertebrate
Fungal Pathogen Reduces Potential for Malaria Transmission
Using a rodent malaria model, we found that exposure to surfaces treated with fungal entomopathogens following an infectious blood meal reduced the number of mosquitoes able to transmit malaria by a…