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Automutilation induced by clonidine in mice.
Clonidine (2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride, St155, Catapres), after administration of a single large dose, was found to induce automutilation in mice housed individually in… Expand
Possible involvement of a central noradrenergic system in automutilation induced by clonidine in mice.
Automutilation induced by a single large dose of clonidine was potentiated by pretreatment with methamphetamine, caffeine and theophyline, while it was inhibited by acute administration of reserpine,… Expand
Cardiovascular changes induced by large doses of clonidine in mice.
Clonidine at doses of 0.5-1.0 mg/kg i.p. produced an initial rise followed by a sustained fall in blood pressure. The initial pressor response became more marked and the onset of hypotensive effect… Expand