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Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine
PURPOSE To assess potential differences in progression-free or overall survival when imatinib mesylate is administered to patients with incurable gastrointestinal stromal tumors (GIST) at a standardExpand
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Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice.
Mice bearing germ line mutations of p53 develop sarcomas at a significant rate. Since they are susceptible to a variety of other malignancies, they are not ideally suited to the study of sarcomas. ToExpand
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Osteosarcoma of the jaw/craniofacial region
The current study was performed to evaluate outcomes in patients with osteosarcoma of the head and neck (OHN) who were treated with surgery with or without radiotherapy (RT).
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Vascular tumors of bone: A study of 17 cases other than ordinary hemangioma, with an evaluation of the relationship of hemangioendothelioma of bone to epithelioid hemangioma, epithelioid
Cases filed as vascular tumor of bone other than ordinary hemangioma were reviewed. They were included in the study if there was adequate histologic material and clinical information, clear evidenceExpand
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A Missense Mutation in KIT Kinase Domain 1 Correlates with Imatinib Resistance in Gastrointestinal Stromal Tumors
KIT gain of function mutations play an important role in the pathogenesis of gastrointestinal stromal tumors (GISTs). Imatinib is a selective tyrosine kinase inhibitor of ABL, platelet-derived growthExpand
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Craniofacial osteosarcomas: plain film, CT, and MR findings in 46 cases.
Forty-six osteosarcomas of the cranial and facial bones were reviewed radiographically by using the conventional parameters for long bone tumors. Expand
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“Dedifferentiated” Chordoma: A Clinicopathologic and Immunohistochemical Study of Three Cases
Three cases of “dedifferentiated” chordoma arising in the sacrococcygeal region are presented. In all three cases, the “dedifferentiated” component arose de novo in conjunction with conventionalExpand
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Prostate cancer cells induce osteoblast differentiation through a Cbfa1-dependent pathway.
Metastases from prostatic adenocarcinoma (prostate cancer) are characterized by their predilection for bone and typical osteoblastic features. An in vitro model of bone metastases from prostateExpand
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Osteosarcoma: MR imaging after preoperative chemotherapy.
The authors reviewed 76 magnetic resonance (MR) images of 38 patients with osteosarcoma treated with preoperative chemotherapy (intraarterial cisplatin with or without systemic chemotherapy).Expand
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Radiation‐induced sarcomas of the chest wall
Sixteen patients are presented who had sarcomas of the chest wall at a site where a prior malignancy had been irradiated. The first malignancies included breast cancer (ten cases), Hodgkin's diseaseExpand
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