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TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling
Cyclic mechanical strain produced by pulsatile blood flow regulates the orientation of endothelial cells lining blood vessels and influences critical processes such as angiogenesis. Mechanical… Expand
A Latent Pro-Survival Function for the Mir-290-295 Cluster in Mouse Embryonic Stem Cells
MicroRNAs (miRNAs) post-transcriptionally regulate the expression of thousands of distinct mRNAs. While some regulatory interactions help to maintain basal cellular functions, others are likely… Expand
Genome-wide impact of a recently expanded microRNA cluster in mouse
- Grace X. Zheng, A. Ravi, G. M. Gould, C. Burge, P. Sharp
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 12 September 2011
Variations in microRNA (miRNA) gene and/or target repertoire are likely to be key drivers of phenotypic differences between species. To better understand these changes, we developed a computational… Expand
Computational Model for Early Cardiac Looping
- A. Ramasubramanian, Kimberly S. Latacha, J. Benjamin, D. Voronov, A. Ravi, L. Taber
- Medicine, Chemistry
- Annals of Biomedical Engineering
- 27 May 2006
Looping is a vital event during early cardiac morphogenesis, as the initially straight heart tube bends and twists into a curved tube, laying out the basic pattern of the future four-chambered heart.… Expand
Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1.
MicroRNAs are a class of short ~22 nucleotide RNAs predicted to regulate nearly half of all protein coding genes, including many involved in basal cellular processes and organismal development.… Expand
Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts.
MicroRNAs (miRNAs) are critical to proliferation, differentiation, and development. Here, we characterize gene expression in murine Dicer-null adult mesenchymal stem cell lines, a fibroblast cell… Expand
Proliferation and Tumorigenesis of a Murine Sarcoma Cell Line in the Absence of DICER 1 Citation
Homologous dura for myringoplasty —An analysis of 120 cases
Homologous dura is an excellent graft material for repairing tympanic membrane perforations. The graft preservation technique is simple and the graft take rate is comparable to grafting with… Expand
Association of metagene based on gene expression with response to atezolizumab (atezo) for metastatic urothelial carcinoma (mUC).
569Background: Despite the benefits of PD1/L1 inhibitors in metastatic urothelial carcinoma (mUC), the durable benefits accrue mostly to a minority of patients (pts) who attain ≥partial response (P...
TQM tools and techniques in promoting team working culture in the manufacturing organisations
Total quality management (TQM) is a management philosophy, a paradigm, a continuous improvement approach for doing business through a new management model. The TQM philosophy evolved from the… Expand