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The genomic signature of dog domestication reveals adaptation to a starch-rich diet
The results indicate that novel adaptations allowing the early ancestors of modern dogs to thrive on a diet rich in starch, relative to the carnivorous diet of wolves, constituted a crucial step in the early domestication of dogs.
Identification of Genomic Regions Associated with Phenotypic Variation between Dog Breeds using Selection Mapping
This study provides a catalogue of genomic regions showing extreme reduction in genetic variation or population differentiation in dogs, including many linked to phenotypic variation.
Detecting positive selection within genomes: the problem of biased gene conversion
- A. Ratnakumar, S. Mousset, M. Webster
- BiologyPhilosophical Transactions of the Royal Society B…
- 27 August 2010
It is shown that genes identified as targets of positive selection have a significant tendency to exhibit the genomic signature of gBGC, a recombination-associated process that results in the biased fixation of G and C nucleotides.
Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome.
- E. Axelsson, M. Webster, A. Ratnakumar, C. Ponting, K. Lindblad-Toh
- BiologyGenome research
- 1 April 2012
It is shown that the PRDM9 gene was inactivated early in canid evolution, resulting in a greater evolutionary stability of recombination hotspots and may reflect a fundamental process of relevance to diverse animal species.
Using comparative genomics to reorder the human genome sequence into a virtual sheep genome
It is demonstrated that limited sequencing of BACs combined with positioning on a well assembled genome and integrating locations from other less well assembled genomes can yield extensive, detailed subgene-level maps of mammalian genomes, for which genomic resources are currently limited.
Simultaneous identification of differential gene expression and connectivity in inflammation, adipogenesis and cancer
The purpose of this communication is to introduce an analytical procedure to simultaneously identify genes that are differentially expressed as well as differentially connected in two or more classes of interest.
AN IMPLEMENTATION OF WEB PERSONALIZATION USING WEB MINING TECHNIQUES
- A. Ratnakumar
- Computer Science
This paper implements how Web mining techniques can be apply for the Customization i.e Web personalization and highlights the significance of studying the evolving nature of the Webpersonalization.
Precision Radiotherapy: Reduction in Radiation for Oropharyngeal Cancer in the 30 ROC Trial.
Deescalation of radiotherapy to 30 Gy on the basis of intratreatment hypoxia imaging was feasible, safe, and associated with minimal toxicity.
Estrogen activates Alzheimer's disease genes
Quality control of the sheep bacterial artificial chromosome library, CHORI-243
The comparative genomic approach can be used to assess BAC library integrity in the absence of fingerprinting and the sequences of the sheep CHORI-243 library BACs have high integrity, especially with the corrections detailed above.