• Publications
  • Influence
Species- and cell type-specific requirements for cellular transformation.
Recent evidence suggests that human cells require more genetic changes for neoplastic transformation than do their murine counterparts. However, a precise enumeration of these differences has neverExpand
  • 528
  • 27
  • Open Access
Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis.
Tumor angiogenesis is postulated to be regulated by the balance between pro- and anti-angiogenic factors. We demonstrate that the critical step in establishing the angiogenic capability of humanExpand
  • 342
  • 8
Introduction of SV40ER and hTERT into mammospheres generates breast cancer cells with stem cell properties
Emerging evidence suggests that cancers arise in stem/progenitor cells. Yet, the requirements for transformation of these primitive cells remains poorly understood. In this study, we have exploitedExpand
  • 28
  • 1
Thrombospondin-1 repression is mediated via distinct mechanisms in fibroblasts and epithelial cells
Tumor-associated angiogenesis is postulated to be regulated by the balance between pro- and anti-angiogenic factors. We demonstrate here that the critical step in establishing the angiogenicExpand
  • 13
Thrombospondin-1 repression is mediated via distinct mechanisms in fibroblasts and epithelial cells
Correction to: Oncogene (2015) 34, 2823–2835; doi: 10.1038/onc.2014.228; published online 11 August 2014 The authors wish to make the readers aware of two errors that were missed at proof stage. TheExpand
  • 10
Effects of Withania somnifera and Tinospora cordifolia Extracts on the Side Population Phenotype of Human Epithelial Cancer Cells
Recent reports suggest the existence of a subpopulation of stem-like cancer cells, termed as cancer stem cells (CSCs), which bear functional and phenotypic resemblance with the adult, tissue-residentExpand
  • 8
Role of Notch Signaling in Human Breast Cancer Pathogenesis
Abstract : Notch proteins are activated upon binding to ligands of the Delta/Serrate family. In previous experiments I had found that activated allele of Notch 1 cooperates with low levels ofExpand
Abstract 2186: Drug treatment induces phenotypic switch and stemness during acquisition of drug resistance
The breast tumor heterogeneity and development of drug resistance has become a challenge for anti-cancer therapy. Tumor cells acquire resistance due to intra-tumor heterogeneity imposed by epithelialExpand