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The specificity of proteasomes: impact on MHC class I processing and presentation of antigens
TLDR
It is found that polypeptide processing is remarkably conserved among proteasomes of enkaryotic origin and that invertebrate proteasome can efficiently produce known high‐copy MHC class I ligands, suggesting evolutionary adaptation of the transporter associated with antigen processing and MHCclass I to ancient constraints imposed by proteasomal protein’ degradation.
Crystal Structure of an Archaeal Pentameric Riboflavin Synthase in Complex with a Substrate Analog Inhibitor
TLDR
The topology of the two bound ligands at the active site is well in line with the known stereochemistry of a pentacyclic adduct of 6,7-dimethyl-8-ribityllumazine that has been shown to serve as a kinetically competent intermediate of trimeric and pentameric riboflavin synthases.