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Illustration of Bayesian Inference in Normal Data Models Using Gibbs Sampling
Abstract The use of the Gibbs sampler as a method for calculating Bayesian marginal posterior and predictive densities is reviewed and illustrated with a range of normal data models, includingExpand
Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients.
Analysis of PK/PD relationships indicates that the initial hematologic response depends on the administered dose for patients with chronic myeloid leukemia. Expand
A Bayesian approach to nonlinear random effects models.
Nonlinear random effects models are considered from the Bayesian point of view and the numerical method is related to the EM algorithm. Expand
Confirmatory adaptive designs with Bayesian decision tools for a targeted therapy in oncology.
It is shown that the use of appropriately stratified logrank tests in the adaptive test procedure guarantees overall type I error control also when using information on patients that are censored at the adaptive interim analysis. Expand
Bayesian Analysis of Linear and Non‐Linear Population Models by Using the Gibbs Sampler
Abstract : A fully Bayesian analysis of linear and nonlinear population models has previously been unavailable, as a consequence of the seeming impossibility of performing the necessary numericalExpand
Population pharmacokinetics of imatinib mesylate in patients with chronic-phase chronic myeloid leukaemia: results of a phase III study.
AIMS This study was designed to investigate the biochemical and physiological covariates or comedications that affect the pharmacokinetics of imatinib mesylate in patients with chronic-phase chronicExpand
Efficacy, pharmacodynamics, and pharmacokinetics of CGP 51901, an anti‐immunoglobulin E chimeric monoclonal antibody, in patients with seasonal allergic rhinitis
The efficacy, pharmacodynamics, and pharmacokinetics of CGP 51901, a recombinant monoclonal mouse—human chimeric anti‐human immunoglobulin E (IgE) antibody were evaluated for patients with seasonal allergic rhinitis and a sustained 85% or greater reduction of serum free IgE levels was shown to be effective in improving clinical symptoms. Expand
The Population Approach: Rationale, Methods, and Applications in Clinical Pharmacology and Drug Development
Since the seminal paper in 1972, “population pharmacokinetics” has been an area of active research in clinical pharmacology, despite scepticism among many pharmacokineticists, most clinicians, and, with rare exceptions, general indifference or even antagonism within the pharmaceutical industry. Expand
An interaction study with cimetidine and the new angiotensin II antagonist valsartan
The pharmacokinetics of cimetidine – area under curve (AUC0–48 h), maximum concentration (Cmax), time to reach Cmax (tmax) and apparent terminal plasma half-life (t1/2) – was not changed by co-administration of valsartan. Expand
Bayesian predictive power for interim adaptation in seamless phase II/III trials where the endpoint is survival up to some specified timepoint.
An adaptive seamless phase II/III trial design is proposed for studies where the endpoint is survival up to some specified timepoint and where Bayesian predictive power (PP) guides interim adaptations. Expand