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Influence of sex and stress exposure across the lifespan on endophenotypes of depression: focus on behavior, glucocorticoids, and hippocampus
Sex differences exist in vulnerability, symptoms, and treatment of many neuropsychiatric disorders. In this review, we discuss both preclinical and clinical research that investigates how sexExpand
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  • Open Access
Parity modifies the effects of fluoxetine and corticosterone on behavior, stress reactivity, and hippocampal neurogenesis
The postpartum confers considerable risk for developing depression. Depressed patients have elevated cortisol concentrations and impaired hypothalamic-pituitary-adrenal (HPA) axis negative feedback.Expand
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Sex differences in depression: Insights from clinical and preclinical studies
HighlightsWomen are more likely than men to present with depression.Women are more likely to present with comorbid anxiety and somatic symptoms.Sex hormones may be an effective adjuvant therapy.SexExpand
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Maternal postpartum corticosterone and fluoxetine differentially affect adult male and female offspring on anxiety-like behavior, stress reactivity, and hippocampal neurogenesis
Postpartum depression (PPD) affects approximately 15% of mothers, disrupts maternal care, and can represent a form of early life adversity for the developing offspring. Intriguingly, male and femaleExpand
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Sex-dependent effects of maternal corticosterone and SSRI treatment on hippocampal neurogenesis across development
BackgroundPostpartum depression affects approximately 15% of mothers and represents a form of early life adversity for developing offspring. Postpartum depression can be treated with prescriptionExpand
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Voluntary running influences the efficacy of fluoxetine in a model of postpartum depression
ABSTRACT Postpartum depression affects approximately 15% of mothers. Unfortunately, treatment options for postpartum depression are limited. Pharmacological antidepressants such as fluoxetine (FLX)Expand
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Sex, hormones, and genotype interact to influence psychiatric disease, treatment, and behavioral research
Sex differences exist in the vulnerability, incidence, manifestation, and treatment of numerous neurological and psychiatric diseases. Despite this observation prominent in the literature, littleExpand
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Maternal exercise increases but concurrent maternal fluoxetine prevents the increase in hippocampal neurogenesis of adult offspring
Treating postpartum depression (PPD) with pharmacological antidepressants like fluoxetine (FLX) is complicated because these drugs can remain active in breast milk and potentially affect infantExpand
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  • Open Access
Folic acid, but not folate, regulates different stages of neurogenesis in the ventral hippocampus of adult female rats
Folate is an important regulator of hippocampal neurogenesis, and in utero spinal cord development. Due to the fortification of folic acid in our food, women may be receiving higher doses ofExpand
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Comparison of pharmacological and non-pharmacological antidepressants in postpartum depression: outcomes of mother and male and female offspring
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