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Distinct Notch signaling outputs pattern the developing arterial system
Differentiation of arteries and veins is essential for the development of a functional circulatory system. In vertebrate embryos, genetic manipulation of Notch signaling has demonstrated theExpand
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Vegfa signals through ERK to promote angiogenesis, but not artery differentiation
Vascular endothelial growth factor a (Vegfa) is essential for blood vessel formation and can induce activation of numerous signaling effectors in endothelial cells. However, it is unclear how andExpand
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BMP signaling orchestrates photoreceptor specification in the zebrafish pineal gland in collaboration with Notch
A variety of signaling pathways have been shown to regulate specification of neuronal subtype identity. However, the mechanisms by which future neurons simultaneously process information fromExpand
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Notch resolves mixed neural identities in the zebrafish epiphysis
Manipulation of Notch activity alters neuronal subtype identity in vertebrate neuronal lineages. Nonetheless, it remains controversial whether Notch activity diversifies cell fate by regulating theExpand
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Robust Identification of Developmentally Active Endothelial Enhancers in Zebrafish Using FANS-Assisted ATAC-Seq.
Identification of tissue-specific and developmentally active enhancers provides insights into mechanisms that control gene expression during embryogenesis. However, robust detection of theseExpand
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CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity
The acetyltransferases CBP and P300 have been implicated in myogenesis in mouse immortalized cell lines but these studies focused only on the expression of a handful of myogenic factors. Hence, theExpand
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Spécification des sous-types neuronaux dans la glande pinéale du poisson zèbre
Cell fate diversification is a prerequisite for the formation of a functional vertebrate nervous system. Given the high level of complexity of the vertebrate nervous system, understanding the basesExpand
Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity
During development, the vertebrate vasculature undergoes major growth and remodeling. While the transcriptional cascade underlying blood vessel formation starts to be better characterized, little isExpand