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Association of circulating TNF-alpha and IL-6 with ageing and parkinsonism.
INTRODUCTION We propose that the increase in TNF-alpha and IL-6 in the brain in idiopathic parkinsonism is in response to a peripheral immune/ inflammatory process, so ubiquitous as to be responsibleExpand
A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease
Mutations in the park2 gene, encoding the RING-inBetweenRING-RING E3 ubiquitin ligase parkin, cause 50% of autosomal recessive juvenile Parkinsonism cases. More than 70 known pathogenic mutationsExpand
Association of circulating TNF‐α and IL‐6 with ageing and parkinsonism
Introduction ‐ We propose that the increase in TNF‐α and IL‐6 in the brain in idiopathic parkinsonism is in response to a peripheral immune/ inflammatory process, so ubiquitous as to be responsibleExpand
RET recognition of GDNF-GFRα1 ligand by a composite binding site promotes membrane-proximal self-association.
The RET receptor tyrosine kinase is essential to vertebrate development and implicated in multiple human diseases. RET binds a cell surface bipartite ligand comprising a GDNF family ligand and a GFRαExpand
The X-ray Crystal Structure of Human γS-crystallin C-terminal Domain*
γS-crystallin is a major human lens protein found in the outer region of the eye lens, where the refractive index is low. Because crystallins are not renewed they acquire post-translationalExpand
aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization
Summary Atypical protein kinase C (aPKC) is a key apical-basal polarity determinant and Par complex component. It is recruited by Par3/Baz (Bazooka in Drosophila) into epithelial apical domainsExpand
Urochordate βγ-Crystallin and the Evolutionary Origin of the Vertebrate Eye Lens
A refracting lens is a key component of our image-forming camera eye; however, its evolutionary origin is unknown because precursor structures appear absent in nonvertebrates [1]. The vertebrateExpand
Urochordate betagamma-crystallin and the evolutionary origin of the vertebrate eye lens.
A refracting lens is a key component of our image-forming camera eye; however, its evolutionary origin is unknown because precursor structures appear absent in nonvertebrates. The vertebrateExpand
Structure of the cohesin loader Scc2
The functions of cohesin are central to genome integrity, chromosome organization and transcription regulation through its prevention of premature sister-chromatid separation and the formation of DNAExpand
Structure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection
Summary The combination of an E2 ubiquitin-conjugating enzyme with an E3 ubiquitin-ligase is essential for ubiquitin modification of a substrate. Moreover, the pairing dictates both the substrateExpand
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