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Magnesium gates glutamate-activated channels in mouse central neurones
TLDR
The voltage dependence of the NMDA receptor-linked conductance appears to be a consequence of the voltage dependenceof the Mg2+ block and its interpretation does not require the implication of an intramembrane voltage-dependent ‘gate’. Expand
The third helix of the Antennapedia homeodomain translocates through biological membranes.
TLDR
It is reported here that a polypeptide of 16 amino acids in length corresponding to the third helix of the homeodomain deleted of its N-terminal glutamate is still capable of translocating through the membrane, suggesting an energy-independent mechanism of translocation not involving classical endocytosis. Expand
Experience-Dependent Transfer of Otx2 Homeoprotein into the Visual Cortex Activates Postnatal Plasticity
TLDR
The experience-dependent transfer of a homeoprotein may establish the physiological milieu for postnatal plasticity of a neural circuit. Expand
Cell Internalization of the Third Helix of the Antennapedia Homeodomain Is Receptor-independent*
TLDR
The present demonstration, that a reverse helix and a helix composed of D-enantiomers still translocate across biological membranes at 4 and 37°C strongly suggests that the third helix of the homeodomain is internalized by a receptor-independent mechanism. Expand
Otx2 Binding to Perineuronal Nets Persistently Regulates Plasticity in the Mature Visual Cortex
TLDR
The pharmacological use of the Otx2 GAG binding domain offers a novel, potent therapeutic tool with which to restore cortical plasticity in the mature brain. Expand
Trojan peptides: the penetratin system for intracellular delivery.
TLDR
The unexpected properties of penetratins, a class of peptides with translocating properties and capable of carrying hydrophilic compounds across the plasma membrane, are summarized, allowing direct targeting of oligopeptides and oligonucleotides to the cytoplasm and nucleus. Expand
Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone
TLDR
It is shown that the subventricular zone (SVZ) of the lateral ventricle, the largest neurogenic area of the adult brain, is a major sAPP binding site and that binding occurs on progenitor cells expressing the EGF receptor. Expand
The transcription factor Engrailed-2 guides retinal axons
TLDR
The differential guidance of nasal and temporal axons reported here suggests that En-2 may participate directly in topographic map formation in the vertebrate visual system. Expand
How can drug discovery for psychiatric disorders be improved?
TLDR
Experts in multiple areas of neuroscience considered key questions in the field, in particular those related to the importance of neuronal plasticity, to propose steps that can be taken to improve the effectiveness of drug discovery for psychiatric disorders. Expand
Antennapedia homeobox peptide regulates neural morphogenesis.
TLDR
The results demonstrate that neurons possess an efficient uptake system for the antennapedia homeobox peptide and suggest that binding of pAntp to consensus motifs present in nerve cell nuclei influences neuronal morphogenetic programs. Expand
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