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Neuropeptide Y stimulates neuronal precursor proliferation in the post‐natal and adult dentate gyrus
Adult dentate neurogenesis is important for certain types of hippocampal‐dependent learning and also appears to be important for the maintenance of normal mood and the behavioural effects ofExpand
Raised parenchymal interleukin-6 levels correlate with improved outcome after traumatic brain injury.
Previous studies have suggested that an increased production of the pro-inflammatory cytokines interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) can influence patient outcome following a severeExpand
Neuroprotection by both NMDA and non-NMDA receptor antagonists in in vitro ischemia
We have investigated the relative contributions of oxygen and glucose deprivation to ischaemic neurodegeneration in organotypic hippocampal slice cultures. Cultures prepared from 10-day-old rats wereExpand
Differential Vulnerability of the CA1 and CA3 Subfields of the Hippocampus to Superoxide and Hydroxyl Radicals In Vitro
Abstract: The relative roles of the superoxide and hydroxyl radicals in oxidative stress‐induced neuronal damage were investigated using organotypic hippocampal slice cultures. Cultures exposed toExpand
Organotypic cultures as tools for functional screening in the CNS.
A major challenge for the pharmaceutical industry is the development of relevant model systems in which knowledge gained from high-throughput, genomic and proteomic approaches can be integrated toExpand
Attenuation and augmentation of ischaemia‐related neuronal death by tumour necrosis factor‐α in vitro
Upregulation of the pro‐inflammatory cytokine tumour necrosis factor‐α (TNF) occurs rapidly in the brain following ischaemia, although it is unclear whether this represents a neurotoxic orExpand
Selective N-type calcium channel antagonist omega conotoxin MVIIA is neuroprotective against hypoxic neurodegeneration in organotypic hippocampal-slice cultures.
BACKGROUND AND PURPOSE Neuroprotection by antagonists of both L-type and N-type calcium channels occurs in in vivo models of ischemia. The site of action of calcium channel antagonists is unclear,Expand
7‐Hydroxylated epiandrosterone (7‐OH‐EPIA) reduces ischaemia‐induced neuronal damage both in vivo and in vitro
Recent evidence suggests that steroids such as oestradiol reduce ischaemia‐induced neurodegeneration in both in vitro and in vivo models. A cytochrome P450 enzyme termed cyp7b that 7‐hydroxylatesExpand
Interleukin-1β exacerbates hypoxia-induced neuronal damage, but attenuates toxicity produced by simulated ischaemia and excitotoxicity in rat organotypic hippocampal slice cultures
Using organotypic hippocampal slice cultures we have investigated the actions of Interleukin-1 (IL-1) in a number of injury paradigms. Low concentrations of IL-1 potentiated hypoxia-inducedExpand
Transcriptomics of traumatic brain injury: gene expression and molecular pathways of different grades of insult in a rat organotypic hippocampal culture model.
Traumatic brain injury (TBI) is the one of the most common forms of head trauma, and it remains a leading cause of death and disability. It is known that the initial mechanical axonal injury triggersExpand