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[The effect of an extract of sea buckthorn (Hippophae rhamnoides L.) on the healing of experimental skin wounds in rats].
The markedly expressed stimulating effect on the healing process is explained with the rich content of vitamins and microelements (sulfur, selenium, zinc, copper etc.) in the extract used. Expand
Effects of paracetamol and propacetamol on gastric mucosal damage and gastric lipid peroxidation caused by acetylsalicylic acid (ASA) in rats.
- B. Galunska, K. Marazova, +4 authors A. di Massa
- Chemistry, Medicine
- Pharmacological research
- 1 August 2002
The results show that the ASA-induced gastric mucosal damage is accompanied by the development of oxidative stress, evidenced by the accumulation of MDA, and concomitant initial activation of cell antioxidant defences. Expand
Nephrotoxic effect of the specific brain serotonin depletor para-chlorophenylalanine.
- O. Ikonomov, A. Stoynev, I. I. Goranova-Stoyneva, A. Popov, V. Minkova
- Acta physiologica Hungarica
It is found that due to the treatments applied in the protocol used for the investigation of pCPA effect on renin and vasopressin secretion in rats, renal injury was induced as well and the renal function changes after i.pCPA may be due not to brain serotonin depletion-alone, but also to nephrotoxic effect. Expand
[A pharmacological study of the hepatoprotective activity of fructose-1,6-diphosphate].
A fructose-1,6-diphosphate preparation was tested for hepatoprotective activity through biochemical and morphologic studies in experiments on Wistar rats sustaining D-galactosamine- and paracetamole-induced hepatotoxicity, and the benefit observed concerned mostly dystrophic and inflammatory changes in the liver. Expand
Gastroprotective effect of propacetamol against cold/restraint stress ulcers in rats.
- K. Marazova, E. Klouchek, A. Popov, P. Frangov, A. di Massa
- Minerva anestesiologica
- 1 July 1999
It might be concluded that morphine and propacetamol are equipotent in their ability to prevent the stress ulceration in rats. Expand
Effect of roxatidine bismuth citrate (MX1) against acetylsalicylic acid- and indomethacin-induced gastric mucosal damage in rats.
- K. Marazova, E. Klouchek, +5 authors K. Hotta
- Medicine, Chemistry
- Methods and findings in experimental and clinical…
- 1 October 1998
The results of the present study suggest that MX1 has a gastroprotective effect against ASA- and indomethacin-induced ulcers which might be due both to its H2-blocking and mucus-stimulating activity. Expand
Gastroprotective Effect of MX1 (a Novel Salt of the Active Metabolite of Roxatidine with a Complex of Bismuth and Citric Acid) Against Stress Ulcers in Rats
- K. Marazova, E. Klouchek, A. Popov, C. Ivanov, I. Krushkov
- Medicine, Chemistry
- The Journal of pharmacy and pharmacology
- 1 August 1997
The effect of the newly synthesized agent MX1, a salt of the active metabolite of the H2‐blocker roxatidine with a complex of bismuth and citric acid, against restraint stress ulcers in rats is studied. Expand
Changes in the severity of haloperidol catalepsy in rats under chronic administration of neuroleptics
When evaluating the cataleptogenic effect of haloperidol 15 days after the chronic use of antipsychotics, a tendency to reduce the time of preservation of the «lecturer’s pose» by rats was revealed in comparison with the control group of animals. Expand
Effect of chronic administration of fluoxetine, melatonin and their combination on the timecourse of the circadian rhythm of motor activity in rats
дромом. Пародонтология. 2011;(2):28-31. [Orekhova L. Yu., Kuchumova Ye. D., Barmasheva A. A. Periodontal status in patients with metabolic syndrome. Parodontologiya. – Periodontology. 2011;(2):28-31.… Expand