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High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program.
Comparing the effect of 5 days' culture in high glucose concentration versus normal glucose levels or hyperosmolar control on the survival of human pancreatic islets suggests that in human islets, high glucose may modulate the balance of proapoptotic and antiap optotic Bcl proteins toward apoptosis, thus favoring beta-cell death. Expand
Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events, and evidence-based glucagon-like peptide 1 receptor agonists should be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events. Expand
Hypocaloric high-protein diet improves glucose oxidation and spares lean body mass: comparison to hypocaloric high-carbohydrate diet.
- P. Piatti, F. Monti, +7 authors G. Pozza
- Biology, Medicine
- Metabolism: clinical and experimental
- 1 December 1994
In conclusion, the experience suggests that a hypocaloric diet providing a high percentage of natural protein can improve insulin sensitivity; and conversely, a Hypocaloric high-polysaccharide-CHO diet decreases insulin sensitivity and is unable to spare muscle tissue. Expand
Microbiota in anorexia nervosa: The triangle between bacterial species, metabolites and psychological tests
The hypothesis that the gut dysbiosis could take part in the AN neurobiology, in particular in sustaining the persistence of alterations that eventually result in relapses after renourishment and psychological therapy, is corroborated. Expand
Post-surgery Adherence to Scheduled Visits and Compliance, More than Personality Disorders, Predict Outcome of Bariatric Restrictive Surgery in Morbidly Obese Patients
Adherence to scheduled visits and compliance to recommended rules, more than personality disorders, predict success of LAGB, at least during the first 4 years. Expand
C-174G polymorphism in the promoter of the interleukin-6 gene is associated with insulin resistance.
Results indicate that the -174G/G genotype of the IL-6 gene may contribute to variations in insulin sensitivity, suggesting that the polymorphism was affecting insulin sensitivity by regulatingIL-6 plasma levels. Expand
Long-term Prevention of Mortality in Morbid Obesity Through Bariatric Surgery. A Systematic Review and Meta-analysis of Trials Performed With Gastric Banding and Gastric Bypass
It is indicated that bariatric surgery reduces long-term mortality; risk reduction is smaller in large than in small studies; and both gastric banding and gastric by-pass reduce mortality with a greater effect of the latter on CV mortality. Expand
Hypertriglyceridemia and Hyperinsulinemia Are Potent Inducers of Endothelin-1 Release in Humans
Subjects with syndrome × showed higher endothelin-1 levels than normal subjects and subjects with insulinoma, and these levels were reproduced in normal subjects by a simultaneous increase in insulin and triglyceride levels. Expand
The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes.
Results indicate that the -866A/A genotype of the UCP2 gene may contribute to diabetes susceptibility by affecting insulin sensitivity. Expand
Female sexual dysfunction and diabetes: a systematic review and meta-analysis.
FSD is more frequent in diabetic than in control women, but it is still poorly understood; low FSFI is associated with high BMI. Expand