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Virulence factor regulation and regulatory networks in Streptococcus pyogenes and their impact on pathogen-host interactions.
Streptococcus pyogenes (group A streptococcus, GAS) is a very important human pathogen with remarkable adaptation capabilities. Survival within the harsh host surroundings requires sensing potentialExpand
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Group A streptococcal growth phase‐associated virulence factor regulation by a novel operon (Fas) with homologies to two‐component‐type regulators requires a small RNA molecule
A novel growth phase‐associated two‐component‐type regulator, Fas (fibronectin/fibrinogen binding/haemolytic activity/streptokinase regulator), of Streptococcus pyogenes was identified in the M1Expand
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Lmb, a Protein with Similarities to the LraI Adhesin Family, Mediates Attachment of Streptococcus agalactiae to Human Laminin
ABSTRACT Streptococcus agalactiae is a leading cause of neonatal sepsis and meningitis. Adherence to extracellular matrix proteins is considered an important factor in the pathogenesis of infection,Expand
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M‐related protein (Mrp) contributes to group A streptococcal resistance to phagocytosis by human granulocytes
The M protein has been postulated to be a major group A streptococcal (GAS) virulence factor because of its contribution to the bacterial resistance to opsono‐phagocytosis. Direct evidence of thisExpand
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The group A streptococcal virR49 gene controls expression of four structural vir regulon genes.
Within a genomic locus termed the vir regulon, virR genes of opacity factor-nonproducing (OF-) group A streptococci (GAS) are known to control the expression of the genes encoding M protein (emm) andExpand
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Characterization of nra, a global negative regulator gene in group A streptococci
During sequencing of an 11.5 kb genomic region of a serotype M49 group A streptococcal (GAS) strain, a series of genes were identified including nra (negative regulator of GAS). TranscriptionalExpand
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Characterization of Biofilm Formation by Clinically Relevant Serotypes of Group A Streptococci
ABSTRACT Streptococcus pyogenes (group A streptococcus [GAS]) is a frequent cause of purulent infections in humans. As potentially important aspects of its pathogenicity, GAS was recently shown toExpand
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Novel series of plasmid vectors for gene inactivation and expression analysis in group A streptococci (GAS).
Ten novel streptococcal shuttle vectors for genomic integration and allelic replacements have been constructed based on plasmid pSF152. These vectors can replicate in E. coli, but not in streptococciExpand
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What is the size of the group A streptococcal vir regulon? The Mga regulator affects expression of secreted and surface virulence factors
Abstract The vir regulon of group A streptococci (GAS) organizes the expression of several bacterial virulence factors under the control of the Mga regulator. Previously, the genes encoding the MgaExpand
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Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial.
BACKGROUND Recently, fungal elements were suspected to be the causative agent of chronic rhinosinusitis, and benefits of topical amphotericin B therapy have been reported. OBJECTIVE The effects ofExpand
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