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Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting
Direct DNA cloning based on the discovery that the full-length Rac prophage protein RecE and its partner RecT mediate highly efficient linear-linear homologous recombination mechanistically distinct from conventional recombineering mediated by Redαβ from lambda phage or truncated versions of RecET is described. Expand
Mirabamides A-D, depsipeptides from the sponge Siliquariaspongia mirabilis that inhibit HIV-1 fusion.
Four new cyclic depsipeptides termed mirabamides A-D (1-4) have been isolated from the marine sponge Siliquariaspongia mirabilis and shown to potently inhibit HIV-1 fusion and demonstrate that these peptides can act at the early stages of HIV- 1 entry. Expand
Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ.
Eight new antimicrobial natural products named chrysophaentins A-H belonging to a new structural class have been isolated from the marine chrysophyte alga Chrysophaeum taylori and are characterized by the presence of two polyhalogenated, polyoxygenated omega,omega'-diarylbutene units connected by two ether bonds to form the suite of macrocyclic natural products. Expand
Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae).
In vivo the anti-inflammatory activity of two Cat's claw bark extracts was assessed, by comparing a spray-dried hydroalcoholic extract against an aqueous freeze-Dried extract, to determine which extract was more effective and it cannot be excluded that the slight inhibitory activity on DNA binding of NF-kappa B is due to cytotoxic effects. Expand
Investigation of the tuber constituents of maca (Lepidium meyenii Walp.).
The methanol extract of the tuber of maca contained (1R,3S)-1-methyltetrahydro-beta-carboline-3-carboxylic acid, a molecule which is reported to exert many activities on the central nervous system. Expand
Celebesides A-C and theopapuamides B-D, depsipeptides from an Indonesian sponge that inhibit HIV-1 entry.
Six new depsipeptides belonging to two different structural classes, termed celebesides A-C and theopapuamides B-D, have been isolated from the marine sponge Siliquariaspongia mirabilis using extensive 2D NMR and ESI-MS/MS techniques. Expand
Largamides A-H, unusual cyclic peptides from the marine cyanobacterium Oscillatoria sp.
Seven new depsipeptides, termed largamides A-G (1-7), and one new cyclic peptide, largamide H (8), have been isolated from the marine cyanobacterium Oscillatoria sp. Their structures were determinedExpand
Aetheramides A and B, potent HIV-inhibitory depsipeptides from a myxobacterium of the new genus "Aetherobacter".
Aetheramides are structurally distinctive cyclic peptides isolated from a novel myxobacterial genus proposed to be termed "Aetherobacter" and showed cytostatic activity against human colon carcinoma cells with IC(50) values of 0.11 μM. Expand
Mutremdamide A and koshikamides C-H, peptide inhibitors of HIV-1 entry from different Theonella species.
The combination of mutremdamide A, koshikamides, and theonellamides appears to define a new Theonella chemotype that can be found in deeper waters. Expand