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Long-term synaptic depression in the striatum: physiological and pharmacological characterization
TLDR
Data show that striatal LTD requires three main physiological and pharmacological conditions: (1) membrane depolarization and action potential discharge of the postsynaptic cell during the conditioning tetanus, (2) activation of glutamate metabotropic receptors, and (3) coactivation of D1 and D2 DA receptors. Expand
The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease
TLDR
A key role for NMS in the clinical frame of PD is supported and the need to address them specifically in clinical trials using dedicated scales is addressed. Expand
Long‐term Potentiation in the Striatum is Unmasked by Removing the Voltage‐dependent Magnesium Block of NMDA Receptor Channels
TLDR
The findings show that repetitive activation of cortical inputs can induce long‐term changes of synaptic transmission in the striatum and this structure may provide the cellular substrate for motor learning and underlie the physiopathology of some movement disorders. Expand
Re-emergence of striatal cholinergic interneurons in movement disorders
TLDR
A review of recent experimental and clinical studies on striatal cholinergic interneurons in Parkinson's disease and dystonia places them within the context of the pathogenesis of movement disorders. Expand
Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice
TLDR
Results reveal a critical role for PINK1 in DA release and striatal synaptic plasticity in the nigrostriatal circuit and suggest that altered dopaminergic physiology may be a pathogenic precursor to nigrostRIatal degeneration. Expand
Acetylcholine-mediated modulation of striatal function
TLDR
It is proposed that endogenous ACh exerts a complex modulation of striatal synaptic transmission, which produces both short-term and long-term effects and might be of crucial importance in processing the cortical inputs to the striatum. Expand
Abnormal Synaptic Plasticity in the Striatum of Mice Lacking Dopamine D2 Receptors
TLDR
This study indicates that D2Rs play a key role in mechanisms underlying the direction of long-term changes in synaptic efficacy in the striatum and shows that an imbalance between D2R and NMDA receptor activity induces altered synaptic plasticity at corticostriatal synapses. Expand
Receptor Subtypes Involved in the Presynaptic and Postsynaptic Actions of Dopamine on Striatal Interneurons
TLDR
Immunohistochemical analyses in both wild-type and D1R-/- mice confirmed the expression of D5 receptors in both cholinergic and parvalbumin-positive interneurons of the striatum, and in mice lacking D2 receptors, the DA-dependent inhibition of GABA transmission was lost in both interneuron populations. Expand
Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1
TLDR
An essential role for DJ-1 in dopaminergic physiology and D2 receptor-mediated functions is suggested in dopamine overflow in the striatum and in the inhibitory effects of D2 autoreceptor stimulation. Expand
Synaptic transmission in the striatum: from plasticity to neurodegeneration
TLDR
The use of the in vitro brain slice preparation has allowed not only the detailed investigation of the direct pre- and postsynaptic electrophysiological actions of several neurotransmitters in striatal neurones, but also the understanding of their role in two different forms of corticostriatal synaptic plasticity, long- term depression and long-term potentiation. Expand
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