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Potential role of activated macrophages in acetaminophen hepatotoxicity. I. Isolation and characterization of activated macrophages from rat liver.
Twenty-four hours following treatment of rats with the analgesic acetaminophen (1.2 g/kg), we observed an infiltration of mononuclear cells into centrilobular regions of the liver in the absence ofExpand
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Effect of cytokines on polymorphonuclear neutrophil infiltration in the mouse. Prostaglandin- and leukotriene-independent induction of infiltration by IL-1 and tumor necrosis factor.
The i.p. injection of mice with highly purified recombinant human rIL-1 alpha or beta resulted in the rapid influx of a large number of polymorphonuclear neutrophils (PMN) into the peritoneal cavity.Expand
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Potential role of activated macrophages in acetaminophen hepatotoxicity. II. Mechanism of macrophage accumulation and activation.
Treatment of rats with acetaminophen (1.2 g/kg) results in the accumulation of activated macrophages in the centrilobular regions of the liver. To study the mechanism by which these cells accumulateExpand
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Activation of liver macrophages following phenobarbital treatment of rats
Phenobarbital is a potent inducer of hepatic cytochrome P‐450 and is a tumor promoter in the two‐stage model of liver carcinogenesis. In the present studies, we show that phenobarbital also inducesExpand
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FDA comments on phase I clinical trials without vector biodistribution data
326 nature genetics • volume 22 • august 1999 hood estimate of linkage disequilibrium D (ref. 5) was 0.71 (P<0.005), confirming the presence of moderate to strong linkage disequilibrium between the 2Expand
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A method for obtaining and culturing large numbers of purified organ‐derived murine endothelial cells
Fibroblast growth factor 1 (FGF‐1)–coated collagen‐gelatin sponges were affixed to various tissues to generate vascular beds, in which the vessels originated in the tissue to which the sponges wereExpand
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Accumulation of Activated Mononuclear Phagocytes in the Liver Following Lipopolysaccharide Treatment of Rats
Lipopolysaccharide (LPS) is a toxic bacterial cell wall component that is rapidly cleared from the portal circulation by Kupffer cells. To determine if interaction with LPS causes the accumulationExpand
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Augmentation of mouse liver-associated natural killer activity by biologic response modifiers occurs largely via rapid recruitment of large granular lymphocytes from the bone marrow.
A variety of biologic response modifiers (BRM) can potently augment NK activity in nonlymphoid organs. By using the liver as a model organ, we have shown that this augmentation of organ-associated NKExpand
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Functional and Biochemical Properties of Rat Kupffer Cells and Peritoneal Macrophages
Functional and biochemical techniques were used to further characterize heterogeneity between rat Kupffer cells and peritoneal macrophages. Both macrophage cell types were found to phagocytizeExpand
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Purification and cloning of a novel serine protease, RNK-Tryp-2, from the granules of a rat NK cell leukemia.
We have biochemically purified a 27-kDa serine protease (designated RNK-Tryp-2) from the granules of the rat large granular lymphocyte leukemia cell line (RNK-16) which has tryptase activity.Expand
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