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On the current management of osteosarcoma. A critical evaluation and a proposal for a modified treatment strategy.
The current management of osteosarcoma (OS) is critically reviewed and a modified treatment strategy is put forward for discussion. The overall treatment results in high-grade OS are less impressiveExpand
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Mechanism of action of the toxic lectins abrin and ricin
The mechanism of action of the plant toxins abrin and ricin is described. The toxins inhibit protein synthesis probably by inactivating the 60S ribosomal subunits, interfering with chain elongation.Expand
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Isolation and comparison of galactose-binding lectins from Abrus precatorius and Ricinus communis.
Abstract The agglutinins present in the seeds of Abrus precatorius and Ricinus communis have been separated from the toxins, abrin and ricin, and extensively purified. The procedure involves ionExpand
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Isolation and characterization of viscumin, a toxic lectin from Viscum album L. (mistletoe).
A toxic protein, viscumin, was isolated from extracts of mistletoe by affinity chromatography on acid-treated Sepharose 4B. Viscumin was selectively bound to the column and could be eluted withExpand
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Pharmacological studies of ricin in mice and humans
SummaryA highly sensitive enzyme-linked immunosorbent assay (ELISA) for determination of ricin in serum is presented. Using this method it was found that IV-injected ricin disappeared from the plasmaExpand
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Characteristics of a cell line established from a patient with multiple osteosarcoma, appearing 13 years after treatment for bilateral retinoblastoma
An osteosarcoma cell line, OHS, was established from a patient with multiple skeletal manifestations of osteosarcoma, developing after bilateral retinoblastoma. The tumor cells expressedExpand
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Expression and characteristics of a novel human osteosarcoma-associated cell surface antigen.
The characteristics of a new osteosarcoma-associated cell surface antigen were studied by means of two murine monoclonal antibodies, TP-1 and TP-3, which were found to bind to two different epitopesExpand
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Extrapulmonary, tissue-specific metastasis formation in nude mice injected with FEMX-I human melanoma cells.
FEMX-I human malignant melanoma cells, originating from a lymph node metastasis in a patient, uniquely and selectively produced extrapulmonary metastases after i.v. injection of cells prepared fromExpand
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