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Hereditary hemochromatosis--a new look at an old disease.
For many years, hereditary hemochromatosis was regarded as a clinically and genetically unique entity marked by a classic presentation consisting of diabetes, bronze skin pigmentation, and cirrhosis.Expand
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The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage.
Iron acquisition is a fundamental requirement for many aspects of life, but excess iron may result in formation of free radicals that damage cellular constituents. For this reason, the amount of ironExpand
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STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo.
BACKGROUND & AIMS Hepcidin is a peptide hormone that is central to the regulation of iron homeostasis. In response to interleukin 6 (IL-6), hepatocytes produce hepcidin that decreases ironExpand
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Iron regulatory proteins in pathobiology.
The capacity of readily exchanging electrons makes iron not only essential for fundamental cell functions, but also a potential catalyst for chemical reactions involving free-radical formation andExpand
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Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene.
Hemochromatosis is a progressive iron overload disorder that is prevalent among individuals of European descent. It is usually inherited in an autosomal-recessive pattern and associated with missenseExpand
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The ferroportin disease
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Gluconeogenic Signals Regulate Iron Homeostasis via Hepcidin in Mice
Background & Aims Hepatic gluconeogenesis provides fuel during starvation, and is abnormally induced in obese individuals or those with diabetes. Common metabolic disorders associated with activeExpand
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Ferroportin disease: pathogenesis, diagnosis and treatment
Ferroportin Disease (FD) is an autosomal dominant hereditary iron loading disorder associated with heterozygote mutations of the ferroportin-1 (FPN) gene. It represents one of the commonest causes ofExpand
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Hemochromatosis: An endocrine liver disease
This review acknowledges the recent and dramatic advancement in the field of hemochromatosis and highlights the surprising analogies with a prototypic endocrine disease, diabetes. The termExpand
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Hepcidin in human iron disorders: therapeutic implications.
The discovery of hepcidin has triggered a virtual explosion of studies on iron metabolism and related disorders, the results of which have profoundly changed our view of human diseases associatedExpand
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