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Low-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial.
Low-dose prophylactic indomethacin significantly lowers the incidence and severity of IVH, particularly the severe form (grade 4 IVH), and is not associated with significant adverse drug events in very low birth weight neonates.
Early diagnosis of neonatal sepsis.
To better define the need for antibiotic therapy, several tests recommended as helpful in diagnosing neonatal sepsis were evaluated and the combination of leukopenia and an elevated band/total neutrophil ratio seems to be particularly predictive of sepsi.
Intraventricular hemorrhage in preterm infants: declining incidence in the 1980s.
The incidence of periventricular-intraventricular hemorrhage was lower in infants born by cesarean section than those delivered vaginally, but the decrease could not be attributed to an increased number of deliveries by cesian section.
Noise and hypoxemia in the intensive care nursery.
The results of measures taken in one NICU to quantitate and lower the ambient noise levels are reported and it is shown that these measures reduce the noise levels in the unit.
The changing face of neonatal infection: experience at a regional medical center.
- A. Philip
- MedicineThe Pediatric infectious disease journal
- 1 December 1994
The incidence, etiology and timing of neonatal infection were assessed in a regional neonatal intensive care unit from 1983 through 1992 and there was a marked decrease in very early onset sepsis in 1988 to 1992 especially in very low birth weight infants, possibly attributable to increased use of prenatal antibiotics.
Use of C-Reactive Protein in Minimizing Antibiotic Exposure: Experience With Infants Initially Admitted to a Well-Baby Nursery
Using a clinical pathway for neonatal sepsis, which is based primarily on CRP determinations, can minimize antibiotic exposure and shorten hospital stays.
Excessive handling as a cause of hypoxemia.
Continuous transcutaneous oxygen (TcPo2) monitoring was used to study low-birth-weight infants (15 control, 15 experimental) during their stay in the intensive care nursery (ICN). Twenty hours of…
Risk factors for early intraventricular hemorrhage in low birth weight infants.
Multivariate analysis indicated that the mode of delivery, fetal presentation, and birth weight were important and independent prognostic indicators of IVH.
Neonatal mortality rate: is further improvement possible?
- A. Philip
- MedicineThe Journal of pediatrics
- 1 March 1995
During the decade, the gestational age at which there was a 50% survival rate fell from 26 weeks to 24 weeks and a marked increase in the survival rate occurred at birth weights < 1500 gm (VLBW) after the introduction of exogenous surfactant therapy.
Antenatal steroids, delivery mode, and intraventricular hemorrhage in preterm infants.
- L. Ment, W. Oh, R. Ehrenkranz, A. Philip, C. Duncan, R. Makuch
- MedicineAmerican journal of obstetrics and gynecology
- 1 March 1995
These data are the first to suggest that both antenatal steroids and cesarean section delivery have an important and independent role in lowering the risk of early-onset intraventricular hemorrhage.