A. Perrone

Publications16
h-index8
Citations208
Highly Influential Citations6
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How to Improve the Early Diagnosis of Trypanosoma cruzi Infection: Relationship between Validated Conventional Diagnosis and Quantitative DNA Amplification in Congenitally Infected Children
Background According to the Chagas congenital transmission guides, the diagnosis of infants, born to Trypanosoma cruzi infected mothers, relies on the detection of parasites by INP micromethod,… Expand
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Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review
The most neglected aspects of Chagas disease (CD) have been patient care and treatment. Despite recent progress in the development of potentially improved drugs, there is no consensus among different… Expand
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Trypanosoma cruzi: biological characterization of a isolate from an endemic area and its susceptibility to conventional drugs.
We describe some biological and molecular characteristics of a Trypanosoma cruzi isolate derived from a Triatomine captured in Nicaragua. PCR based typification showed that this isolate, named… Expand
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Trypanosoma cruzi Infection at the Maternal-Fetal Interface: Implications of Parasite Load in the Congenital Transmission and Challenges in the Diagnosis of Infected Newborns
Trypanosoma cruzi is the protozoan unicellular parasite that causes Chagas disease. It can be transmitted from infected mothers to their babies via the connatal route, thus being able to perpetuate… Expand
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A homolog of cyclophilin D is expressed in Trypanosoma cruzi and is involved in the oxidative stress–damage response
Mitochondria have an important role in energy production, homeostasis and cell death. The opening of the mitochondrial permeability transition pore (mPTP) is considered one of the key events in… Expand
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Oxidative stress damage in the protozoan parasite Trypanosoma cruzi is inhibited by Cyclosporin A.
Cyclosporin A (CsA) specifically inhibits the mitochondrial permeability transition pore (mPTP). Opening of the mPTP, which is triggered by high levels of matrix [Ca2+] and/or oxidative stress, leads… Expand
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Some Limitations for Early Diagnosis of Congenital Chagas Infection by PCR
Case report of an infrequent diagnosis of congenital Trypanosoma cruzi infection, causative agent of Chagas disease, negative for parasite diagnosis until 7 months after delivery. Trypanosoma cruzi,… Expand
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Phenotypic diversity and drug susceptibility of Trypanosoma cruzi TcV clinical isolates
Trypanosoma cruzi is a genetically heterogeneous group of organisms that cause Chagas disease. It has been long suspected that the clinical outcome of the disease and response to therapeutic agents… Expand
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Morphological and biological characterization of cell line developed from bovine Echinococcus granulosus
The taeniid tapeworm Echinococcus granulosus is the causative agent of echinococcal disease, a major zoonosis with worldwide distribution. Several efforts to establish an in vitro model of E.… Expand
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Mitochondrial permeability transition in protozoan parasites: what we learned from Trypanosoma cruzi
Mitochondrial permeability transition in protozoan parasites: what we learned from Trypanosoma cruzi
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