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A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma.
TLDR
A signaling pathway is identified that downregulates BCL6 expression in normal GC B cells and is blocked in a subset of DLBCL due to alterations in the BCL 6 gene. Expand
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis
TLDR
Using multidimensional cytometry, transcriptomics, and functional assays, a population of PD-1hiCXCR5− ‘peripheral helper’ T (TPH) cells that express factors enabling B-cell help, including IL-21, CXCL13, ICOS, and MAF are defined. Expand
Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice.
TLDR
The findings uncover a crucial link among ROCK2, IRF4, and the production of IL-17 and IL-21 and support the idea that selective inhibition of ROCK2 could represent an important therapeutic regimen for the treatment of autoimmune disorders. Expand
IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor.
TLDR
IBP appears to be important in preventing T cell-mediated autoimmunity by ensuring that the production of IL-17 and IL-21 does not occur in response to self-antigens. Expand
Enhancer-Mediated Control of Macrophage-Specific Arginase I Expression1
TLDR
It is shown that Th2-inducible arginase I expression in mouse macrophages is controlled by an enhancer that lies −3 kb from the basal promoter that provides potential to manipulate arginases I activity in immune cells while sparing liver urea cycle function. Expand
Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system.
TLDR
Findings indicate that IBP is a novel type of GEF, which participates in the activation of Rho GTPases in lymphoid tissues, which is similar to SWAP-70 whose expression is primarily restricted to B cells. Expand
Lineage-Specific Modulation of Interleukin 4 Signaling by Interferon Regulatory Factor 4
TLDR
The studies indicate that interferon regulatory factor (IRF)-4 is both a target and a modulator of the IL-4 signaling cascade, and it is found that IRF-4 can interact with signal transducer and activator of transcription (Stat)6 and drive the expression ofIL-4–inducible genes. Expand
Modulation of T Cell Cytokine Production by Interferon Regulatory Factor-4*
TLDR
Stable expression of IRF-4 in Jurkat T cells not only leads to a strong enhancement in the synthesis of interleukin (IL)-2, but also enables these cells to start producing considerable amounts of IL-4, IL-10, and IL-13. Expand
Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity.
TLDR
It is demonstrated that loss of IBP leads to the spontaneous development of a systemic autoimmune disorder characterized by the accumulation of effector/memory T cells and IgG+ B cells, profound hypergammaglobulinemia, and autoantibody production. Expand
JAK-STAT signaling in asthma.
TLDR
This review highlights the recent advances made in dissecting the roles of this signaling pathway in the pathogenesis of asthma by revealing that cytokine-mediated signals are primarily transduced by the Jak-Stat signaling cascade. Expand
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