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The release of a bradykinin‐like pulmonary vasodilator substance in foetal and new‐born lambs
1. Exposure to glass of whole blood from anaesthetized foetal lambs (at 0·6‐0·95 of term) causes the rapid development of a potent pulmonary vasodilator agent.
Studies of factors which stimulate lung fluid secretion in fetal goats.
  • S. Cassin, A. Perks
  • Chemistry, Medicine
  • Journal of developmental physiology
  • 1 October 1982
The results suggest that the fetal lungs may influence salt-water balance, and this may be under prolactin control. Expand
The effects of arginine vasopressin and epinephrine on lung liquid production in fetal goats.
AVP appears to act at plasma levels found in most vaginal deliveries; it may augment epinephrine-induced reabsorption during stress, and help long-term removal of lung fluid. Expand
The kinin system and ovulation: changes in plasma kininogens, and in kinin-forming enzymes in the ovaries and blood of rats with 4-day estrous cycles.
  • C. Smith, A. Perks
  • Chemistry, Medicine
  • Canadian journal of physiology and pharmacology
  • 1 July 1983
It seems possible that LH induces kinin-forming enzymes in the ovaries, and induces a later activation of plasma enzymes, to produce kinins which may be involved in vascular and permeability changes important in ovulation, and perhaps concerned in the mechanisms of positive feed-back with the pituitary. Expand
Amiloride inhibits arginine vasopressin-induced decrease in fetal lung liquid secretion.
AVP in conjunction with other hormones that are elevated during the stress of birth (epinephrine and cortisol) may be important in the removal of lung fluid at birth. Expand
Fluid production by in vitro lungs from near-term fetal guinea pigs: effects of cortisol and aldosterone.
The highest steroid concentrations tested corresponded to plasma concentrations in the guinea pig at delivery; therefore, it is suggested that both steroids may have a role in reducing lung fluid production close to birth in this species. Expand
The effect of dopamine on lung liquid production by in vitro lungs from fetal guinea‐pigs
  • B. Chua, A. Perks
  • Chemistry, Medicine
  • The Journal of physiology
  • 1 November 1998
It is suggested that internal release of dopamine by the neuroendocrine system of the lungs may influence lung liquid reabsorption at birth. Expand
Effects of intravenous saline infusion on fetal ovine lung liquid secretion.
The results demonstrate that 1) intravenous infusion of saline at relatively high rates in the ovine fetus does not affect net fetal lung liquid formation rate, and 2) the lungs of chronically catheterized, unanesthetized fetal sheep probably do not participate in regulation of excess fluid and electrolytes. Expand
Estimation of lung liquid production in fetal sheep with blue dye dextran and radioiodinated serum albumin.
The data suggest that there was no significant difference in production or reabsorption rates measured by BDD or RISA, differences in volumes measured by the two indicators were only significant if gestational age was ignored and were too small to have physiological importance, and although BDD and RISA each may have methodological weaknesses, for purposes of measuring lung liquid volumes both are sufficiently accurate and reproducible to obtain meaningful physiological results. Expand