A. Perelson

Publications672
h-index115
Citations64,248
Highly Influential Citations3,261
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • R. Ribeiro
  • 206 Publications • 9,154 Citations
  • R. Siliciano
  • 412 Publications • 39,966 Citations
  • B. Haynes
  • 935 Publications • 79,493 Citations
  • G. Shaw
  • 400 Publications • 60,910 Citations
  • Publications
  • Influence
Self-nonself discrimination in a computer
TLDR
A method for change detection which is based on the generation of T cells in the immune system is described, which reveals computational costs of the system and preliminary experiments illustrate how the method might be applied to the problem of computer viruses.
View on IEEE
HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time
TLDR
A new mathematical model was used to analyze a detailed set of human immunodeficiency virus-type 1 (HIV-1) viral load data collected from five infected individuals after the administration of a potent inhibitor of HIV-1 protease, providing not only a kinetic picture ofAIDS pathogenesis, but also theoretical principles to guide the development of treatment strategies.
View on Publisher
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
TLDR
Treatment of infected patients with ABT-538 causes plasma HIV-1 levels to decrease exponentially and CD4 lymphocyte counts to rise substantially, indicating that replication of HIV- 1 in vivo is continuous and highly productive, driving the rapid turnover ofCD4 lymphocytes.
View on Springer
Mathematical Analysis of HIV-1 Dynamics in Vivo
TLDR
It is shown how dynamical modeling and parameter estimation techniques have uncovered important features of HIV pathogenesis and impacted the way in which AIDS patients are treated with potent antiretroviral drugs.
View via Publisher
Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
TLDR
A mathematical model of random viral evolution and phylogenetic tree construction is developed and used to analyze 3,449 complete env sequences derived by single genome amplification from 102 subjects with acute HIV-1 (clade B) infection, suggesting a finite window of potential vulnerability of HIV- 1 to vaccine-elicited immune responses, although phenotypic properties of transmitted Envs pose a formidable defense.
View on Publisher
Decay characteristics of HIV-1-infected compartments during combination therapy
TLDR
It is estimated that 2.3–3.1 years of a completely inhibitory treatment would be required to eliminate HIV-1 from these compartments, and even longer treatment may be needed because of the possible existence of undetected viral compartments or sanctuary sites.
View on Springer
Nonlinear dynamics of immunogenic tumors: parameter estimation and global bifurcation analysis.
View on PubMed
Kinetics of Influenza A Virus Infection in Humans
TLDR
A series of mathematical models of increasing complexity, which incorporate target cell limitation and the innate interferon response, are utilized to examine influenza A virus kinetics in the upper respiratory tracts of experimentally infected adults to suggest that antiviral treatments have a large hurdle to overcome in moderating symptoms and limiting infectiousness.
View on ASMUSA
The immune system, adaptation, and machine learning
View via Publisher
Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy
TLDR
Findings show that infection with hepatitis C virus is highly dynamic and that early monitoring of viral load can help guide therapy, with blocking efficacies of 81, 95, and 96% for daily doses of 5, 10, and 15 million international units, respectively.
View via Publisher
...
...