A. Perelson
- Publications
- Influence
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Proceedings of IEEE Computer Society Symposium…
The problem of protecting computer systems can be viewed generally as the problem of learning to distinguish self from other. The authors describe a method for change detection which is based on the… Expand
A new mathematical model was used to analyze a detailed set of human immunodeficiency virus-type 1 (HIV-1) viral load data collected from five infected individuals after the administration of a… Expand
Treatment of infected patients with ABT-538, an inhibitor of the protease of human immuno-deficiency virus type 1 (HIV-1), causes plasma HIV-1 levels to decrease exponentially (mean half-life, 2.1… Expand
Mathematical models have proven valuable in understanding the dynamics of HIV-1 infection in vivo. By comparing these models to data obtained from patients undergoing antiretroviral drug therapy, it… Expand
The precise identification of the HIV-1 envelope glycoprotein (Env) responsible for productive clinical infection could be instrumental in elucidating the molecular basis of HIV-1 transmission and in… Expand
Analysis of changes in viral load after initiation of treatment with potent antiretroviral agents has provided substantial insight into the dynamics of human immunodeficiency virus type 1 (HIV-1)1–3.… Expand
We present a mathematical model of the cytotoxic T lymphocyte response to the growth of an immunogenic tumor. The model exhibits a number of phenomena that are seen in vivo, including… Expand
Abstract The immune system is capable of learning, memory, and pattern recognition. By employing genetic operators on a time scale fast enough to observe experimentally, the immune system is able to… Expand
ABSTRACT Currently, little is known about the viral kinetics of influenza A during infection within an individual. We utilize a series of mathematical models of increasing complexity, which… Expand
IEEE Transactions on Systems, Man, and…
Multiport Systems and Bond Graphs Basic Component Models System Models State-Space Equations Analysis of Linear Systems Multiport Fields and Junction Structures Transducers, Amplifiers, and… Expand