A. Perazzi

Publications27
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Citations133
Highly Influential Citations2
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Pharmacokinetics and metabolism of deflazacort in the rat, dog, monkey and man.
Pharmacokinetics and metabolism of premazepam, a new potential anxiolytic, in humans.
TLDR
Of the three metabolites identified in the urine, none was active in vitro in displacing 3H-diazepam from its forebrain receptors in the rat, indicating that only the parent compound has definite pharmacologic activity.
Metabolism of deflazacort in the rat, dog and man.
TLDR
In the formation of metabolites I-V the fused 2-methyloxazoline ring is unmetabolized, whereas the steroid moiety follows the general metabolic pathways reported for other related corticosteroids.
Studies of binding C3-substitute rifamycins to human and bovine serum albumin.
TLDR
The interactions of a series of C3-substituted rifamycins with human and bovine serum albumins were studied to suggest the inhibition by protein of the antibacterial activities of these antibiotics depends on the type of bonding mechanism rather than the degree of binding.
Separation of phenolic O-glucuronides and phenolic sulphate esters by multiple liquid-liquid partition
Species differences in the disposition and metabolism of 1-methyl-3-(3-pyridyl)-5-(2-hydroxy-methylphenyl)-1H-1,2,4-triazole, a potential sedative-hypnotic compound.
TLDR
The species differences in the disposition and metabolism of the new sedative-hypnotic are consistent with previous pharmacological data indicating a greater and more prolonged effect in cat.
Metabolic pathways of the contragestational agent, 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole (DL 111-IT), in the rat.
TLDR
The metabolic pathways of the non-hormonal anti-fertility agent 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole were studied in rats given the 14C-labelled compound intramuscularly, indicating that the unchanged drug is the active molecule.
Metabolism of 5-isopropyl-1-methyl-2-nitro-1H-imidazole. Identification of some urinary metabolites in the dog.
TLDR
The metabolism of 5-isopropyl-1-methyl-2-nitro-1H-[2-14C] imidazole in dogs has been investigated after oral administration of 50 mg/kg and the metabolic behavior appears to be similar to that previously demonstrated for the class of the isomeric 5-Nitroimidazoles.
Pharmacokinetics-activity relationships of a new non-hormonal antifertility agent: 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1, 2,4-triazole, in the rat and the hamster
TLDR
A comparison between the kinetic profiles and the activity data after single or multiple dose administration in different formulations clearly indicates a close relationship between activity and plasma and tissue levels of DL 111-IT, and makes clear the influence of the formulation and of the treatment schedule on the anti-fertility activity of the compound.
Social policies in relation to employment and pregnancy in European countries.
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