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Induction of malignant bone tumors in rats by 1-(2-hydroxyethyl)-1-nitrosourea.
Forty male MRC-W rats were treated chronically with 1-(2-hydroxyethyl)-1-nitrosourea in drinking water (total dose, 330 mg/rat). Fifteen rats (38%) developed osteogenic osteosarcomas orExpand
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Effect of sodium ascorbate on tumor induction in rats treated with morpholine and sodium nitrite, and with nitrosomorpholine.
Groups of male MRC Wistar rats were treated for 2 years either with morpholine (10 g/kg food) together with sodium nitrite (3 g/l drinking water) or with N-nitrosomorpholine (NM, 0.15g/l drinkingExpand
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Histology of Chemically Induced Mesotheliomas in Mrc-wistar Rats 1
Two peritoneal mesotheliomas were induced in rats during a carcinogenicity study of 1-nitroso-5,6-dihydrouracil (NO-DHU) injected intraperitoneally. A review of literature concerning experimentalExpand
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Carcinogenicity test of six nitrosamides and a nitrosocyanamide administered orally to rats.
Six nitrosamides [ethylnitrosourea (ENU), 2-hydroxyethylnitrosourea (HENU), carboxymethylnitrosourea, 1-nitroso-5,6-dihydrouracil (NDHU), 1-nitrosohydantoin, and N-methyl-N-nitrosobenzamide (MNB)]Expand
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Early vascular modifications induced by asbestos fibers in the hamster cheek pouch.
Abstract The vascular response of the hamster cheek pouch to direct application of five UICC-standardized types of asbestos fibers was studied in vivo by the transparent chamber technique. TheExpand
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Arsenic and cancer: the still unanswered question.
  • A. Pelfrene
  • Medicine
  • Journal of toxicology and environmental health
  • 1 July 1976
For some 2,500 years, arsenic was considered an important element of pharmacopeias and was praised for its medicinal qualities. However, an incidental link with cancer was suggested during theExpand
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Carcinogenic activity of anthanthrene on mouse skin
Dibenzo [cd, jk] pyrene (anthanthrene), considered to be noncarcinogenic, was examined for carcinogenicity in a comparative study with other polycyclic hydrocarbons. Anthanthrene induced benign andExpand
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Comment on Methodology and Interpretation of Results
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A search for a suitable animal model for bone tumors: a review.
There is an obvious need for an adequate animal model for the study of chemically induced bone tumors. A review of the literature has indicated only a limited number of incidental or deliberateExpand
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