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Histochemistry: Theoretical and Applied
A. G. E. Pearse is a relative newcomer to the field of histochemistry. He holds an M.D. degree from the University of Cambridge and is now Lecturer in Histochemistry at the Postgraduate MedicalExpand
THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPT
  • A. Pearse
  • Biology, Medicine
  • The journal of histochemistry and cytochemistry…
  • 1 May 1969
TLDR
A group of apparently unrelated endocrine cells, some in endocrine glands, others in nonendocrine tissues, share a number of cytochemical and ultrastructural characteristics which indicate the possession of a common metabolic pattern and common synthetic, storage and secretion mechanisms. Expand
The solitary active cells histochemical demonstration of damage-resistant nerve cells with a TPN-diaphorase reaction
TLDR
Histoehemieally demonstrable cells which are no t morphological ly distinguishable with the light microscope are described and their special metabolic function is stressed. Expand
The Cytochemical Localization of Oxidative Enzymes
TLDR
Although diaphorase systems are implicated in the reduction of tetrazolium salts, specific dehydrogenases are solely responsible for the distinct distribution pattern obtained in tissues with various substrates. Expand
5-Hydroxytryptophan Uptake by Dog Thyroid ‘C’ Cells, and its Possible Significance in Polypeptide Hormone Production
  • A. Pearse
  • Chemistry, Medicine
  • Nature
  • 6 August 1966
5-Hydroxytryptophan Uptake by Dog Thyroid ‘C’ Cells, and its Possible Significance in Polypeptide Hormone Production
The APUD concept and hormone production.
  • A. Pearse
  • Medicine
  • Clinics in endocrinology and metabolism
  • 1 July 1980
TLDR
In 1968 the acron ym APUD was attached to a series of cells, which appeared to possess a significant number of common cytochemical and ultrastructural properties, and the origin of all the APUD cells were presumed, at that time, to originate from endodermal precursors. Expand
Direct Relationship of Phosphorylase and Mitochondrial α-Glycerophosphate Dehydrogenase Activity in Skeletal Muscle
  • A. Pearse
  • Chemistry, Medicine
  • Nature
  • 1 July 1961
PREVIOUS work1 showed that in mammalian and avian muscle fibres there was a reciprocal relationship between phosphorylase and the oxidative enzymes, as shown by histochemical techniques. Two groupsExpand
The diffuse neuroendocrine system and the apud concept: related "endocrine" peptides in brain, intestine, pituitary, placenta, and anuran cutaneous glands.
TLDR
It is postulated that cells derived at different periods of time from the embryonic epiblast--or perhaps, more accurately, ectoblast--they share a common neuroendocrine programme, manifested by their possession of the acronymous amine-handling characteristics of the series and whose final expression is determined by microenvironmental circumstances. Expand
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