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E/Z-rubrolide O, an anti-inflammatory halogenated furanone from the New Zealand ascidian Synoicum n. sp.
Bioassay-directed fractionation of extracts of a Synoicum n. sp. ascidian from New Zealand led to the isolation of the principal anti-inflammatory component, which was identified by spectroscopic…
Natural product growth inhibitors of Mycobacterium tuberculosis.
This review covers natural products (secondary metabolites) with reported growth inhibitory activity towards Mycobacterium tuberculosis or related organisms with the express intent of identifying novel scaffolds for the development of new antituberculosis agents.
Anti-inflammatory thiazine alkaloids isolated from the New Zealand ascidian Aplidium sp.: inhibitors of the neutrophil respiratory burst in a model of gouty arthritis.
Two new tricyclic thiazine-containing quinolinequinone alkaloids were isolated from the New Zealand ascidian Aplidium species and inhibited the in vitro production of superoxide by PMA-stimulated human neutrophils in a dose-dependent manner.
Isodiplamine, cystodytin K and lissoclinidine: novel bioactive alkaloids from the New Zealand ascidian Lissoclinum notti
anti-Tuberculosis natural products: synthesis and biological evaluation of pyridoacridine alkaloids related to ascididemin
Anti-inflammatory and antimalarial meroterpenoids from the New Zealand ascidian Aplidium scabellum.
- Susanna T. S. Chan, A. Pearce, +7 authors B. Copp
- Chemistry, MedicineThe Journal of organic chemistry
- 3 October 2011
Bioassay-directed fractionation of an extract of the New Zealand ascidian Aplidium scabellum has afforded the anti-inflammatory secondary metabolite 2-geranyl-6-methoxy-1,4-hydroquinone-4-sulfate (1)…
Didemnidines A and B, indole spermidine alkaloids from the New Zealand ascidian Didemnum sp.
- Rhys Finlayson, A. Pearce, +5 authors B. Copp
- Biology, MedicineJournal of natural products
- 24 February 2011
Two new indole spermidine alkaloids, didemnidines A (1) and B (2), have been isolated from the New Zealand ascidian Didemnum sp. The structures of the metabolites, determined by analysis of 2D NMR…
Synthesis and anti-inflammatory structure-activity relationships of thiazine-quinoline-quinones: inhibitors of the neutrophil respiratory burst in a model of acute gouty arthritis.
Synthesis and antimalarial evaluation of artesunate-polyamine and trioxolane-polyamine conjugates.
Discovery and Evaluation of Thiazinoquinones as Anti-Protozoal Agents
Pure compound screening has identified the dioxothiazino-quinoline-quinone ascidian metabolite ascidiathiazone A to be a moderate growth inhibitor of Trypanosoma brucei rhodesiense and Plasmodium falciparum while exhibiting low levels of cytotoxicity.