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Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment
The Microbiota Makes for Good Therapy The gut microbiota has been implicated in the development of some cancers, such as colorectal cancer, but—given the important role our intestinal habitants playExpand
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Interaction of colloidal gold nanoparticles with human blood: effects on particle size and analysis of plasma protein binding profiles.
Nanoparticle size and plasma binding profile contribute to a particle's longevity in the bloodstream, which can have important consequences for therapeutic efficacy. In this study an approximateExpand
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Method for analysis of nanoparticle hemolytic properties in vitro.
Hemolysis (destruction of red blood cells) in vivo can lead to anemia, jaundice, and other pathological conditions; therefore the hemolytic potential of all intravenously administered pharmaceuticalsExpand
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Characterization of nanoparticles for therapeutics.
Nanotechnology offers many advantages to traditional drug design, delivery and medical diagnostics; however, nanomedicines present considerable challenges for preclinical development. NanoparticleExpand
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Design and Function of a Dendrimer-Based Therapeutic Nanodevice Targeted to Tumor Cells Through the Folate Receptor
AbstractPurpose. We sought to develop nanoscale drug delivery materials that would allow targeted intracellular delivery while having an imaging capability for tracking uptake of the material. AExpand
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Targeted drug delivery with dendrimers: comparison of the release kinetics of covalently conjugated drug and non-covalent drug inclusion complex.
Dendrimers have unique characteristics including monodispersity and modifiable surface functionality, along with highly defined size and structure. This makes these polymers attractive candidates asExpand
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Zeta potential measurement.
This chapter describes a method for the measurement of the electrostatic potential at the electrical double layer surrounding a nanoparticle in solution. This is referred to as the zeta potential.Expand
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Energy dispersive X‐ray analysis of titanium dioxide nanoparticle distribution after intravenous and subcutaneous injection in mice
In an effort to understand the disposition and toxicokinetics of nanoscale materials, we used EDS (energy dispersive X‐ray spectroscopy) to detect and map the distribution of titanium dioxide (TiO2)Expand
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Lipid bilayer disruption by polycationic polymers: the roles of size and chemical functional group.
Polycationic polymers are used extensively in biology to disrupt cell membranes and thus enhance the transport of materials into the cell. The highly polydisperse nature of many of these materialsExpand
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Lack of significant dermal penetration of titanium dioxide from sunscreen formulations containing nano- and submicron-size TiO2 particles.
Titanium dioxide (TiO(2)) is included in some sunscreen formulations to physically block ultraviolet radiation. A dermal penetration study was conducted in minipigs with three TiO(2) particlesExpand
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