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Dynamic DNA methylation programs persistent adverse effects of early-life stress
Adverse early life events can induce long-lasting changes in physiology and behavior. We found that early-life stress (ELS) in mice caused enduring hypersecretion of corticosterone and alterations inExpand
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Differential role of estrogen receptor isoforms in sex‐specific brain organization
Transient activation of estrogen receptors (ER) in the developing brain during a limited perinatal “window of time” is recognized as a key mechanism of defeminization of neural control ofExpand
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Early-life stress reduces DNA methylation of the Pomc gene in male mice.
Early-life stress (ELS) increases the vulnerability thresholds for stress-related diseases such as major depression and anxiety by inducing alterations in the structure and function of neuralExpand
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Depletion of the neural precursor cell pool by glucocorticoids
Glucocorticoids (GCs) are indicated for a number of conditions in obstetrics and perinatal medicine; however, the neurodevelopmental and long‐term neurological consequences of early‐life GC exposureExpand
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Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress
Early-life stress (ELS) induces long-lasting changes in gene expression conferring an increased risk for the development of stress-related mental disorders. Glucocorticoid receptors (GR) mediate theExpand
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Non-receptor-tyrosine Kinases Integrate Fast Glucocorticoid Signaling in Hippocampal Neurons
Background: The intracellular signaling cascades through which corticosterone rapidly alters neuronal activity are poorly defined. Results: Corticosterone alters glutamatergic transmission byExpand
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Glucocorticoids and neuro- and behavioural development.
Epidemiological evidence links exposure to stress hormones during fetal or early postnatal development with lifetime prevalence of cardiac, metabolic, auto-immune, neurological and psychiatricExpand
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Insidious adrenocortical insufficiency underlies neuroendocrine dysregulation in TIF‐2 deficient mice
The transcription‐intermediary‐factor‐2 (TIF‐2) is a coactivator of the glucocorticoid receptor (GR), and its disruption would be expected to influence glucocorticoid‐mediated control of theExpand
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Experimental models of stress
Illustrating the complexity of the stress response and its multifaceted manifestations is the leading idea of this overview of experimental paradigms used for stress induction in laboratory animals.Expand
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