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Antidepressant‐like activity of CGP 36742 and CGP 51176, selective GABAB receptor antagonists, in rodents
TLDR
Investigation of the antidepressant‐like activity of the selective GABAB receptor antagonists CGP 36742 and CGP 51176 and a selective agonist CGP 44532 in models of depression in rats and mice finds limited data to support this proposition. Expand
Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT₁A/5-HT₂A/5-HT₇ and dopamine D₂/D₃ receptors.
A series of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole was synthesized to explore the influence of two structural features - replacement of ether/amide moiety withExpand
Quinoline- and isoquinoline-sulfonamide analogs of aripiprazole: novel antipsychotic agents?
TLDR
This review presents the state of the development of novel antipsychotic dopaminergic and non-dopaminergic agents and presents the strategic development of long-chain arylpiperazine-derived quinoline- and isoquinoline-sulfonamide displaying a multireceptor binding profile and partial D2 receptor agonism. Expand
Genetic variants in transforming growth factor-β gene (TGFB1) affect susceptibility to schizophrenia
TLDR
It is shown that the association was significant in females, while in males it reached a trend toward statistical significance, and is the first report showing the association between TGFB1 +869T>C polymorphism and schizophrenia. Expand
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
TLDR
It is suggested that DMLs combining 5-HT6R antagonism and D2R partial agonism may successfully target affective disorders in patients from different age groups without a risk of cognitive deficits. Expand
Anxiolytic-like activity of zinc in rodent tests.
TLDR
It is reported that zinc significantly increased the number of entries into the open arms in the elevated plus maze in rats, which may indicate that zinc could be used as a novel therapeutic/adjunct agent in anxiolytic therapy. Expand
Pharmacological evaluation of the anxiolytic-like effects of EMD 386088, a partial 5-HT6 receptor agonist, in the rat elevated plus-maze and Vogel conflict tests
TLDR
It is suggested that EMD 386088, a 5- HT6 receptor agonist, produces anxiolytic-like activity after systemic administration which may result from direct stimulation of 5-HT6 receptors. Expand
Novel 5-HT7R antagonists, arylsulfonamide derivatives of (aryloxy)propyl piperidines: Add-on effect to the antidepressant activity of SSRI and DRI, and pro-cognitive profile.
TLDR
An extended pharmacological profile, especially the augmentation effect of the identified 5-HT7R antagonist on SSRI activity, seems promising regarding the complexity of affective disorders and potentially improved outcomes, including mnemonic performance. Expand
Intragenic Variations in BTLA Gene Influence mRNA Expression of BTLA Gene in Chronic Lymphocytic Leukemia Patients and Confer Susceptibility to Chronic Lymphocytic Leukemia
TLDR
The results indicate that rs1982809 BTLA gene polymorphism is associated with mRNA expression level and that variations in theBTLA gene might be considered as potentially low-penetrating CLL risk factor. Expand
Association of 3' nearby gene BTLA polymorphisms with the risk of renal cell carcinoma in the Polish population.
TLDR
The results indicate that polymorphisms rs1982809 situated in 3' UTR nearby region of BTLA gene might be considered as low-penetrating risk factor for RCC, but results have to be confirmed in further studies. Expand
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