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The preclinical discovery and development of paliperidone for the treatment of schizophrenia
- A. Wesołowska, M. Jastrzębska-Więsek, A. Cios, A. Partyka
- Psychology, MedicineExpert opinion on drug discovery
- 3 May 2018
This review article provides details regarding paliperidone’s pharmacological and neurochemical mechanisms, and their contribution to therapeutic benefits and adverse effects, based on the available literature with respect to the preclinical and clinical findings and product labels.
Quinoline- and isoquinoline-sulfonamide analogs of aripiprazole: novel antipsychotic agents?
- P. Zajdel, A. Partyka, Krzysztof Marciniec, A. Bojarski, M. Pawłowski, A. Wesołowska
- Psychology, MedicineFuture medicinal chemistry
This review presents the state of the development of novel antipsychotic dopaminergic and non-dopaminergic agents and presents the strategic development of long-chain arylpiperazine-derived quinoline- and isoquinoline-sulfonamide displaying a multireceptor binding profile and partial D2 receptor agonism.
Antidepressant‐like activity of CGP 36742 and CGP 51176, selective GABAB receptor antagonists, in rodents
Investigation of the antidepressant‐like activity of the selective GABAB receptor antagonists CGP 36742 and CGP 51176 and a selective agonist CGP 44532 in models of depression in rats and mice finds limited data to support this proposition.
Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT₁A/5-HT₂A/5-HT₇ and dopamine D₂/D₃ receptors.
Genetic variants in transforming growth factor-β gene (TGFB1) affect susceptibility to schizophrenia
It is shown that the association was significant in females, while in males it reached a trend toward statistical significance, and is the first report showing the association between TGFB1 +869T>C polymorphism and schizophrenia.
Towards new 5-HT7 antagonists among arylsulfonamide derivatives of (aryloxy)ethyl-alkyl amines: Multiobjective based design, synthesis, and antidepressant and anxiolytic properties.
Effects of GABAB receptor ligands in rodent tests of anxiety-like behavior.
- A. Partyka, A. Kłodzińska, Andrzej Pilc
- Biology, PsychologyPharmacological reports : PR
- 1 November 2007
It is demonstrated that CGP 36742 is active in several animal tests detecting anxiolytic activity, and the preclinical data further implicate GABA(B) receptor function in anxiety, and support the GABAergic hypothesis of this disorder.
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
Anxiolytic-like activity of zinc in rodent tests.