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Targeting Toll-like receptors: emerging therapeutics?
TLDR
This work focuses on TLRs that hold the most promise for drug discovery research, highlighting agents that are in the discovery phase and in clinical trials, and on the emerging new aspects of TLR-mediated signalling — such as control by ubiquitination and regulation by microRNAs that might offer further possibilities of therapeutic manipulation. Expand
Expression profiling of metalloproteinases and their inhibitors in cartilage.
TLDR
This is the first comprehensive expression profile of all known MMP, ADAMTS, and TIMP genes in cartilage and provides a foundation with which to understand mechanisms of gene regulation in OA and potentially to refine the specificity of antiproteolytic therapies. Expand
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
TLDR
The results suggest that, in human cells, the DNA-damage checkpoint involves direct inactivation of Cdc25 catalyzed by Cds1 and/or Chk1, which is homologous to the CDS1/Rad53 family of checkpoint kinases in yeast. Expand
STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation.
TLDR
An unexpected role for TLR2 in the oncogenic function of STAT3 that may represent a therapeutic target in GC is revealed. Expand
Identification of a Human Homologue of theSchizosaccharomyces pombe rad17 + Checkpoint Gene*
TLDR
To begin to understand the protein-protein interactions of the human checkpoint machinery, the yeast two-hybrid system is used to examine potential interactions between Hrad1, Hrad9, and Hrad17 and it is demonstrated that Hrad 17 is located on chromosome 4q13.3–21.2. Expand
Inhibition of TLR2 promotes graft function in a murine model of renal transplant ischemia‐reperfusion injury
TLDR
It is shown that inhibition of TLR2 with a therapeutic agent (OPN301) provides significant protection from ischemia/reperfusion injury in a model of kidney transplantation and promotes graft function in an isograft model of renal transplantation. Expand
TLR2 and TLR4 in Ischemia Reperfusion Injury
TLDR
The current state of knowledge linking TLR2 and TLR4 to I/R injury is summarized, including recent studies which demonstrate that therapeutic inhibition ofTLR2 has beneficial effects on I-R injury in a murine model of myocardial infarction. Expand
Nurr1 dependent regulation of pro-inflammatory mediators in immortalised synovial fibroblasts
TLDR
Elevated levels of Nurr1 leads to increased gene expression of pro-inflammatory genes: IL-8, Amphiregulin and Kit ligand in a model cell line providing further evidence for an additional role for Nurr 1 in inflammation and may play a role in the pathogenesis of rheumatoid arthritis. Expand
The Schizosaccharomyces pombe rad11+ gene encodes the large subunit of replication protein A
TLDR
The cloning of the largest subunit of RPA (rpa1+) from the fission yeast Schizosaccharomyces pombe shows that the rpa1+ gene is essential for viability and is expressed specifically at S phase of the cell cycle, and proposes that RPA is required to maintain the integrity of replication complexes when DNA replication is blocked. Expand
Toll-like receptors and NOD-like receptors in rheumatic diseases
TLDR
Nalp3 has been identified as a key NLR for IL-1β production and has been shown to have a particular role in gout, presenting new therapeutic opportunities, possibly allowing for the replacement of biologics with small molecule inhibitors. Expand
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