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Bioequivalence: An overview of statistical concepts
The value of testing two one-sided null hypotheses of non-equivalence at a significance level of 0.05, and the importance of estimating a 90% confidence interval of the ratio (test/reference) of mean AUC and C m a x values, and of the difference between mean T m a X values, are now recognized and form the current standards for BE. Expand
The effect of food on the bioavailability of ibuprofen and flurbiprofen from sustained release formulations.
Results indicate that despite a significant increase in peak plasma concentrations of both drugs with a meal, the bioavailability of flurbiprofen alone was enhanced, and qualitative changes in the plasma concentration versus time curves are primarily influenced by the nature of the formulation and the type of meal. Expand
Non-linear pharmacokinetics of rifampicin in healthy Asian Indian volunteers.
Rifampicin obeys two-compartment kinetics with zero order absorption, and exhibits non-linear saturable elimination kinetics as well as large inter-individual variability. Expand
Determination of nicorandil concentrations in human plasma using liquid chromatography.
  • A. Ojha, A. Pargal
  • Medicine, Chemistry
  • Journal of pharmaceutical and biomedical analysis
  • 1 October 1999
Comparative pharmacokinetics and amoebicidal activity of metronidazole and satranidazole in the golden hamster, Mesocricetus auratus.
The data suggest that higher plasma and liver concentrations of satranidazole and greater intrinsic potency probably contribute to superior amoebicidal activity in the hamster model of hepatic infection. Expand
Flurbiprofen Pharmacokinetics: Interstrain and Sex Differences in Rats
Interstrain differences in the pharmacokinetic behaviour of drugs can influence their plasma concentration-time profiles and the extent of drug exposure, thereby influencing the outcome of animalExpand
Pharmacokinetics and amoebicidal activity of (+-)-(E)-3-(4- methylsulphinylstyryl)-1,2,4-oxadiazole (BTI 2286E) and its sulphone metabolite (BTI 2571E) in the golden hamster, Mesocricetus auratus.
The amoebicidal activity of both BTI 2286E and BTI 2571E was evaluated in the acute hamster hepatic model of amoEBiasis and their dose-response profiles were characterized. Expand
Pharmacokinetics of Flosequinan and its Sulphone Metabolite in Asian Indians
The pharmacokinetics of flosequinan, a peripheral vasodilator, and its active sulphone metabolite, flosequinoxan, were investigated in eleven Asian Indian male volunteers, in a phase 1 clinicalExpand