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Idiopathic Pulmonary Fibrosis: Prevailing and Evolving Hypotheses about Its Pathogenesis and Implications for Therapy
TLDR
The hypothesis that idiopathic pulmonary fibrosis is a fibrotic rather than an inflammatory disease is examined, and the therapeutic implications of these findings are discussed.
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The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
TLDR
It is shown that lysophosphatidic acid levels increase in bronchoalveolar lavage fluid following lung injury in the bleomycin model of pulmonary fibrosis, and that mice lacking one of its receptors, LPA1, are markedly protected from fibrosis and mortality in this model.
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Hypersensitivity pneumonitis: insights in diagnosis and pathobiology.
TLDR
The diagnosis of Hypersensitivity pneumonitis requires a high index of suspicion and should be considered in any patient presenting with clinical evidence of interstitial lung disease, making diagnosis extremely difficult.
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Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans
TLDR
The results identify matrilysin as a mediator of pulmonary fibrosis and a potential therapeutic target and illustrate the power of global gene expression analysis of human tissue samples to identify molecular pathways involved in clinical disease.
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Up-Regulation and Profibrotic Role of Osteopontin in Human Idiopathic Pulmonary Fibrosis
TLDR
A potential mechanism by which osteopontin secreted from the alveolar epithelium may exert a profibrotic effect in IPF lungs is provided and osteoponin is highlighted as a potential target for therapeutic intervention in this incurable disease.
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Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis
TLDR
The results suggest that genes involved in host defense, cell-cell adhesion and DNA repair contribute to risk of fibrotic IIPs.
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Idiopathic pulmonary fibrosis
TLDR
The biological processes underlying IPF are thought to reflect an aberrant reparative response to repetitive alveolar epithelial injury in a genetically susceptible ageing individual, although many questions remain on how to define susceptibility.
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Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers.
TLDR
The alveolar epithelium is outlined, and the fibrogenic mechanisms specifically operated by active abnormal epithelial cells are examined, which results from multiple cycles of epithelial cell injury and activation.
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Inhibition and role of let-7d in idiopathic pulmonary fibrosis.
TLDR
The down-regulation of let-7d in IPF and the profibrotic effects of this down- regulation in vitro and in vivo suggest a key regulatory role for this microRNA in preventing lung fibrosis.
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MMP1 and MMP7 as Potential Peripheral Blood Biomarkers in Idiopathic Pulmonary Fibrosis
TLDR
The experiments provide the first evidence for a peripheral blood protein signature in IPF and the two main components, MMP7 and MMP1, are overexpressed in the lung microenvironment and distinguish IPF from other chronic lung diseases.
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