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Common Kibra Alleles Are Associated with Human Memory Performance
Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated withExpand
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GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.
The apolipoprotein E (APOE) epsilon4 allele is the best established genetic risk factor for late-onset Alzheimer's disease (LOAD). We conducted genome-wide surveys of 502,627 single-nucleotideExpand
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GAB2 Alleles Modify Alzheimer's Risk in APOE ɛ4 Carriers
Summary The apolipoprotein E ( APOE ) ɛ4 allele is the best established genetic risk factor for late-onset Alzheimer's disease (LOAD). We conducted genome-wide surveys of 502,627 single-nucleotideExpand
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Low-dose cortisol for symptoms of posttraumatic stress disorder.
OBJECTIVE Because elevated cortisol levels inhibit memory retrieval in healthy human subjects, the present study investigated whether cortisol administration might also reduce excessive retrieval ofExpand
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A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.
OBJECTIVE While the apolipoprotein E (APOE) epsilon allele is a well-established risk factor for late-onset Alzheimer's disease (AD), initial genome scans using microsatellite markers in late-onsetExpand
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Better Memory and Neural Efficiency in Young Apolipoprotein E ε4 Carriers
The apolipoprotein E (APOE) epsilon4 allele is the major genetic risk factor for Alzheimer's disease, but an APOE effect on memory performance and memory-related neurophysiology in young, healthyExpand
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A genetic variation of the noradrenergic system is related to differential amygdala activation during encoding of emotional memories
Emotionally arousing events are typically well remembered, but there is a large interindividual variability for this phenomenon. We have recently shown that a functional deletion variant of ADRA2B,Expand
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A deletion variant of the α2b-adrenoceptor is related to emotional memory in Europeans and Africans
Emotionally arousing events are recalled better than neutral events. This phenomenon, which helps us to remember important and potentially vital information, depends on the activation ofExpand
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24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia.
The brain is the most cholesterol-rich organ in the human body. Accumulation of excess cholesterol in hippocampal neurons promotes the cleavage of the amyloid precursor protein (APP) intoExpand
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The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism
BACKGROUND The risk for posttraumatic stress disorder (PTSD) depends on the number of traumatic event types experienced in a dose-response relationship, but genetic factors are known to alsoExpand
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