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Saffron as a source of novel acetylcholinesterase inhibitors: molecular docking and in vitro enzymatic studies.
Inhibitors of acetylcholine breakdown by acetylcholinesterase (AChE) constitute the main therapeutic modality for Alzheimer's disease. In the search for natural products with inhibitory action onExpand
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Antileukemic and Cytogenetic Activity by Triple Administration of Three Modified Steroidal Derivatives of Nitrogen Mustards
Combination chemotherapy is widely and routinely used for most cancer patients. The main objective of this study is an effort to develop new anticancer drugs and procedures with enhanced antitumorExpand
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Research on the anti-tumour effect of steroid lactam alkylator (NSC-294859) in comparison with conventional chemotherapeutics in malignant melanoma
Evidence indicating that hybrid steroid compounds of anti-cancer agents produce reduced toxicity, significantly lower than the cytotoxic components alone, and increased anti-cancer activity hasExpand
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Induction of cytogenetic damage by modified steroidal derivatives of p-bis(2-chloroethyl)aminophenylacetic acid in human lymphocytes.
The effect of modified steroids, containing alkylating agents, on SCE rates and on cell kinetics in cultured human lymphocytes was studied. The homo-aza-steroidal ester ofExpand
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Enhanced Cytogenetic and Antineoplastic Effects by the Combined Action of Two Esteric Steroidal Derivatives of Nitrogen Mustards
The authors studied the effect of two modified steroids containing different proportions (%) of alkylating agents alone or in combination on sister chromatid exchange (SCE) rates and on humanExpand
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New Compounds: Antitumor Activity of 3β - Hydroxy-13 α - amino -13,17 - seco - 5α- androstan -17 - oic -13,17 - lactam 4-[p-[Bis(2-chloroethyl)amino]phenyl]butyrate
3/β-Hydroxy-l 3α-amino-13,17-seco-5α-androstan-17-oic- 13,17-lactam 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrate was prepared by reacting 4-[p-[bis(2-chloroethyl)amino]phenyl]butyryl chlorideExpand
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Platinum(II) and palladium(II) complexes with 2-acetylpyridine thiosemicarbazone: cytogenetic and antineoplastic effects
The effect of three novel complexes of Pt(II) and three complexes of Pd(II) with 2-acetylpyridine thiosemicarbazone (HAcTsc) on sister chromatid exchange (SCE) rates and human lymphocyteExpand
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Lactandrate: a D-homo-aza-androsterone alkylator in the treatment of breast cancer
SummaryThe sensitivity of breast neoplasms to hormonal control provides the basis of novel investigational treatments with steroidal alkylators. An androsterone D-lactam steroidal ester, theExpand
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Preclinical studies on NSC290205 aza‐steroid alkylator activity in combination with adriamycin against lymphoid leukaemia
NSC290205 (A) is an hybrid synthetic antineoplastic ester that is a combination of a d‐lactam derivative of androsterone and an alkylating derivative of N,N‐bis(2‐chloroethyl)aniline. We testedExpand
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Cytostatic effect of homo-aza-steroidal esters in vivo and in vitro. Structure-activity relationships.
The p-[N,N-bis (2-chloroethyl)amino]phenylacetate esters of 3 beta-hydroxy-N-methyl-17 alpha-aza-D-homo-5 alpha-androstan-17-one and 3 beta-hydroxy-17 alpha-aza-D-homo-5 alpha-androstane have beenExpand
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