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Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern
TLDR
Functional and tissue distribution differences of Livin α and β suggest that Livin may play a complex role in the regulation of apoptosis. Expand
Phase I/II trial of intravenous NDV-HUJ oncolytic virus in recurrent glioblastoma multiforme.
TLDR
The findings of good tolerability and encouraging responses warrant the continued evaluation of NDV-HUJ in GBM, as well as other cancers. Expand
Infection of Specific Dendritic Cells by CCR5-Tropic Human Immunodeficiency Virus Type 1 Promotes Cell-Mediated Transmission of Virus Resistant to Broadly Neutralizing Antibodies
TLDR
Infection of immature mDCs by CCR5-tropic virus can establish a pool of infected cells that can efficiently transfer virus at the same time that they protect virus from antibody neutralization, which may enhance infection, contribute to immune evasion, and could provide a selective advantage for C CR5- Tropic virus transmission. Expand
Modulation of endothelial cell proliferation, adhesion, and motility by recombinant heparin‐binding domain and synthetic peptides from the type I repeats of thrombospondin
TLDR
The results suggest that both the Trp‐Ser‐Xaa‐Trp sequences in the type I repeats and the amino‐terminal domain play roles in the antiproliferative activity of thrombospondin. Expand
Inhibition of transcription of herpes simplex virus immediate early genes in interferon-treated human cells.
TLDR
It is suggested that IFN blocked HSV-1 replication primarily at a very early stage, during the onset of alpha mRNA transcription, which indicated that the IFN-mediated inhibition of HSVs replication is at a stage beyond viral penetration into the cytoplasm. Expand
The Oncolytic Activity of Newcastle Disease Virus NDV-HUJ on Chemoresistant Primary Melanoma Cells Is Dependent on the Proapoptotic Activity of the Inhibitor of Apoptosis Protein Livin
TLDR
NDV-HUJ, a one-cycle replicating virus, overcomes the resistance to apoptosis of melanoma primary cultures that over express the Livin protein and offers the possibility of a new viral oncolytic treatment for chemoresistant melanoma. Expand
Apolipoprotein E: A potent inhibitor of endothelial and tumor cell proliferation
TLDR
Recombinant human apolipoprotein E3, purified from E. coli, inhibited the proliferation of several cell types, including endothelial cells and tumor cells in a dose‐ and time‐dependent manner and suggest that apoE may be effective in modulating angiogenesis, tumor cell growth, and metastasis. Expand
Human peripheral blood eosinophils induce angiogenesis.
TLDR
Eosinophils are found to enhance endothelial cell proliferation and to induce a strong angiogenic response both in the aorta rings and in the chorioallantoic membrane assays, which strongly suggests an important role of eosInophils in angiogenesis-associated diseases such as asthma. Expand
Herpes Simplex Virus Type 1 Latency-Associated Transcripts Suppress Viral Replication and Reduce Immediate-Early Gene mRNA Levels in a Neuronal Cell Line
TLDR
It is proposed that the LATs may repress viral replication in neuronal cells by reducing IE gene mRNA levels and thus facilitate the establishment of HSV-1 latency in nervous tissue. Expand
Low-molecular-weight RNAs of Moloney murine leukemia virus: identification of the primer for RNA-directed DNA synthesis
TLDR
The small RNAs of Moloney murine leukemia virus (M-MuLV) were fractionated into at least 15 species by two-dimensional polyacrylamide gel electrophoresis, and one of the associated molecules is tightly bound to the genome RNA and serves as the major primer for M- MuLV RNA-directed DNA synthesis in vitro. Expand
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