A. Pandey

Publications116
h-index27
Citations3,741
Highly Influential Citations134
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Bacterial Decolorization and Degradation of Azo Dyes
Color has always been a part of human life since long. All colorants, until the middle of nineteenth century, were of natural origin. Manufacturing of synthetic dyes started in 1856 and the first…
CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML).
High-resolution crystal structure of human Protease-Activated Receptor 1 bound to the antagonist vorapaxar
TLDR
The structure of human PAR1 bound to vorapaxar will aid the development of improved PAR1 antagonists and the discovery of antagonists to other members of this receptor family.
Oncogenic RET Receptors Display Different Autophosphorylation Sites and Substrate Binding Specificities (*)
TLDR
The patterns of autophosphorylation of the wild-type RET and the MEN mutants were studied to understand the molecular mechanisms of the disease states caused by mutations in RET, and suggest that the men2B mutation may result in the more aggressive MEN2B phenotype by altering the receptor's signaling capabilities.
High-resolution crystal structure of human protease-activated receptor 1
TLDR
The structure of human PAR1 bound to vorapaxar will aid the development of improved PAR1 antagonists and the discovery of antagonists to other members of this receptor family.
The Selective Syk Inhibitor P505-15 (PRT062607) Inhibits B Cell Signaling and Function In Vitro and In Vivo and Augments the Activity of Fludarabine in Chronic Lymphocytic Leukemia
TLDR
P 505-15 successfully inhibited SYK-mediated B-cell receptor signaling and decreased cell viability in NHL and CLL and combination treatment of primary CLL cells with P505-15 plus fludarabine produced synergistic enhancement of activity at nanomolar concentrations.
Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyrosine kinase family.
TLDR
Oral administration of 75 promotes mice survival and significantly delayed disease progression in a Flt-3/ITD-mediated leukemia mouse model and shows efficacy in a nude mouse model of chronic myelomonocytic leukemia.
Specific Inhibition of Spleen Tyrosine Kinase Suppresses Leukocyte Immune Function and Inflammation in Animal Models of Rheumatoid Arthritis
TLDR
Specific Syk inhibition can mimic Syk genetic deficiency to modulate immune function, providing a therapeutic strategy in P505-15 for the treatment of human diseases.
Evaluation of the Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Hydroxychavicol for Its Potential Use as an Oral Care Agent
TLDR
Hydxychavicol isolated from the chloroform extraction of aqueous extract of Piper betle leaves showed inhibitory activity against oral cavity pathogens and potent antioxidant and anti-inflammatory activities, suggesting it has great potential for use in mouthwash for preventing and treating oral infections.
SYK inhibition and response prediction in diffuse large B-cell lymphoma.
TLDR
The results suggest the possibility of using PLCγ2 and AKT as biomarkers to predict therapeutic response in prospective clinical trials of specific SYK inhibitors, and provide insights into cellular pathways required for lymphoma cell growth.
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