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Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects.
It is demonstrated that apigenin is a ligand for the central benzodiazepine receptors exerting anxiolytic and slight sedative effects but not being anticonvulsant or myorelaxant. Expand
6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS
This paper is the first report of the presence of 2S(-)-hesperidin in valeriana and describes that it has sedative and sleep-enhancing properties, and 6-methylapigenin (MA) was found to have anxiolytic properties and was able to potentiate the sleep- enhancing properties of hesperidIn (HN). Expand
Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora Coerulea
The data suggest that chrysin possesses anxiolytic actions without inducing sedation and muscle relaxation, and postulate that this natural monoflavonoid is a partial agonist of the central BDZ receptors. Expand
Central nervous system depressant action of flavonoid glycosides.
It is demonstrated in this work that these behavioural actions, as measured in the hole board, thiopental induced sleeping time and locomotor activity tests, are unlikely to involve a direct action on gamma-aminobutyric acid type A (GABA(A))) receptors. Expand
Flavonoids and the Central Nervous System: from Forgotten Factors to Potent Anxiolytic Compounds
Semisynthetic derivatives of flavone obtained by introducing halogens, nitro groups or both in its molecule give rise to high affinity ligands for the benzodiazepine receptor, active in‐vivo; 6,3′‐dinitroflavone, for example, is an anxiolytic drug 30 times more potent than diazepam. Expand
Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties.
Administered to mice by the intracerebroventricular route, chrysin was able to prevent the expression of tonic-clonic seizures induced by pentylenetertrazol, which suggests a myorelaxant action of the flavonoid. Expand
Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis
The identification in V. officinalis of the flavone glycoside linarin (LN) and the discovery that it has, like HN, sedative and sleep-enhancing properties that are potentiated by simultaneous administration of valerenic acid (VA). Expand
Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA(A) receptors, from Valeriana wallichii.
Using the guidance by a competitive assay for the benzodiazepine binding site in the GABA(A) receptor, active compounds were isolated from the rhizomes and roots of Valeriana wallichii DC. The UV,Expand
GABA(A)-receptor ligands of flavonoid structure.
The new research developments that have established the CNS-activity of some natural flavonoids are described and a survey of the occurrence of ligands for the benzodiazepine binding site in the flavonoid field is attempted. Expand
Synergistic interaction between hesperidin, a natural flavonoid, and diazepam.
It is demonstrated that 6-Methylapigenin is able to potentiate the sleep-enhancing effect of hesperidin and this property is shared with various GABA(A) receptor ligands, among them the agonist diazepam, which was used to study the potentiation as measured in the hole board test. Expand