6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS
- M. Marder, H. Viola, C. Wasowski, S. Fernandez, J. Medina, A. Paladini
- BiologyPharmacology, Biochemistry and Behavior
- 1 June 2003
Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects.
- H. Viola, C. Wasowski, A. Paladini
- Biology, PsychologyPlanta Medica
- 1 June 1995
It is demonstrated that apigenin is a ligand for the central benzodiazepine receptors exerting anxiolytic and slight sedative effects but not being anticonvulsant or myorelaxant.
Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora Coerulea
- C. Wolfman, H. Viola, A. Paladini, F. Dajas, J. Medina
- Biology, PsychologyPharmacology, Biochemistry and Behavior
- 31 January 1994
Central nervous system depressant action of flavonoid glycosides.
- S. Fernandez, C. Wasowski, M. Marder
- Biology, ChemistryEuropean Journal of Pharmacology
- 13 June 2006
Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties.
- J. Medina, A. Paladini, C. Peña
- BiologyBiochemical Pharmacology
- 15 November 1990
Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis
- S. Fernandez, C. Wasowski, A. Paladini, M. Marder
- BiologyPharmacology, Biochemistry and Behavior
- 1 February 2004
Isolation of pharmacologically active benzodiazepine receptor ligands from Tilia tomentosa (Tiliaceae).
- H. Viola, C. Wolfman, A. Paladini
- BiologyJournal of Ethnopharmacology
- 1 August 1994
GABA(A)-receptor ligands of flavonoid structure.
- M. Marder, A. Paladini
- Chemistry, BiologyCurrent Topics in Medicinal Chemistry
- 31 July 2002
The new research developments that have established the CNS-activity of some natural flavonoids are described and a survey of the occurrence of ligands for the benzodiazepine binding site in the flavonoid field is attempted.
Overview—Flavonoids: A New Family of Benzodiazepine Receptor Ligands
- J. Medina, H. Viola, A. Paladini
- Biology, ChemistryNeurochemical Research
- 1 April 1997
Flavonoid derivatives, such as 6,3′-dinitroflavone were found to have a very potent anxiolytic effect not associated with myorelaxant, amnestic or sedative actions, and could represent an improved therapeutic tool in the treatment of anxiety.
Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA(A) receptors, from Valeriana wallichii.
- C. Wasowski, M. Marder, H. Viola, J. Medina, A. Paladini
- Biology, ChemistryPlanta Medica
- 1 October 2002
Using the guidance by a competitive assay for the benzodiazepine binding site in the GABA(A) receptor, active compounds were isolated from the rhizomes and roots of Valeriana wallichii DC. The UV,…
...
...