A. Pain

Publications281
h-index64
Citations22,783
Highly Influential Citations1,078
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Genome sequence of the human malaria parasite Plasmodium falciparum
TLDR
The genome sequence of P. falciparum clone 3D7 is reported, which is the most (A + T)-rich genome sequenced to date and is being exploited in the search for new drugs and vaccines to fight malaria.
View on Nature
The genome of the social amoeba Dictyostelium discoideum
TLDR
A proteome-based phylogeny shows that the amoebozoa diverged from the animal–fungal lineage after the plant–animal split, but Dictyostelium seems to have retained more of the diversity of the ancestral genome than have plants, animals or fungi.
View on Nature
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
TLDR
The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus and revealed temperature-dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype.
View on Nature
A promoter-level mammalian expression atlas
TLDR
It is found that few genes are truly ‘housekeeping’, whereas many mammalian promoters are composite entities composed of several closely separated TSSs, with independent cell-type-specific expression profiles.
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A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses
TLDR
It is observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3′ untranslated region motif is implicated in this process.
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Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae
TLDR
The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution, and a comparative study with Aspergillus fumigatus and As pergillus oryzae, used in the production of sake, miso and soy sauce, provides new insight into eukaryotic genome evolution and gene regulation.
View on Springer
Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry
TLDR
A large-scale, high-accuracy mass spectrometric proteome analysis of selected stages of the human malaria parasite Plasmodium falciparum revealed 1,289 proteins that contain domains that indicate a role in cell–cell interactions, and therefore can be evaluated as potential components of a malaria vaccine formulation.
View on Nature
Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells
TLDR
It is shown that intact malaria-infected erythrocytes adhere to dendritic cells, inhibit the maturation of dendedritic cells and subsequently reduce their capacity to stimulate T cells, demonstrating both a novel mechanism by which malaria parasites induce immune dysregulation and a functional role beyond endothelial adhesion for the adhesive phenotypes expressed at the surface of infected ery Throcytes.
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A robust SNP barcode for typing Mycobacterium tuberculosis complex strains
TLDR
This SNP-based barcode is the first to cover all main lineages, and classifies a greater number of sublineages than current alternatives, and may be used to classify clinical isolates to evaluate tools to control the disease.
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The Systematic Functional Analysis of Plasmodium Protein Kinases Identifies Essential Regulators of Mosquito Transmission
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