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Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states.
TLDR
The distinct localization of TIMP-1 and MMP expression during CNS inflammation suggests a dynamic state in which the interplay between these gene products may determine both the size and resolution of the destructive inflammatory focus. Expand
Gliosarcoma: a clinical study.
TLDR
Clinical features, treatment, survival and patterns of failure, gliosarcomas and GBM cannot be distinguished clinically and the same principles should be applied for the treatment of these tumors. Expand
IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis.
TLDR
The results reveal that Tc17 cells contribute to the initiation of CNS autoimmunity in mice and humans by supporting Th17 cell pathogenicity. Expand
Malignant Pineal Parenchymal Tumors in Adult Patients: Patterns of Care and Prognostic Factors
TLDR
Stage, histological characteristics, and response are independent risk factors in adults with malignant pineal parenchymal tumors in a multicenter, retrospective study. Expand
Nuclear Factor I X Deficiency Causes Brain Malformation and Severe Skeletal Defects
TLDR
The knockout analysis of the fourth and last member of this gene family, Nfix, is reported and it is shown that the expression level of tetranectin, a plasminogen-binding protein involved in mineralization, is specifically downregulated in bones of NFIX-deficient mice. Expand
Dysfunction of axonemal dynein heavy chain Mdnah5 inhibits ependymal flow and reveals a novel mechanism for hydrocephalus formation.
TLDR
It is shown that ependymal cilia generate a laminar flow of cerebrospinal fluid through the cerebral aqueduct, which is referred to as 'ependymal flow' and is essential for ultrastructural and functional integrity of ependedymalcilia. Expand
C10 is a novel chemokine expressed in experimental inflammatory demyelinating disorders that promotes recruitment of macrophages to the central nervous system.
TLDR
C10 is a prominent chemokine expressed in the central nervous system in experimental inflammatory demyelinating disease that, it is shown, also acts as a potent chemotactic factor for the migration of these leukocytes to the brain. Expand
Metalloproteinase Disintegrins ADAM8 and ADAM19 Are Highly Regulated in Human Primary Brain Tumors and their Expression Levels and Activities Are Associated with Invasiveness
TLDR
Investigating the expression levels of cerebrally expressed ADAM genes in human primary brain tumors demonstrated that the proteases exert enhanced proteolytic activity in those tumor specimens with the highest expression levels, indicating that ADAM8 and ADAM19 may play a significant role in tumor invasion that may be detrimental to patients survival. Expand
A two-hit mechanism causes cerebral cavernous malformations: complete inactivation of CCM1, CCM2 or CCM3 in affected endothelial cells
TLDR
These data are the first to demonstrate endothelial cell mosaicism within cavernous tissues and provide clear pathogenetic evidence that the endothelialcells of known germline mutation carriers are the cell of disease origin. Expand
The TIMPs tango with MMPs and more in the central nervous system
TLDR
The current state of knowledge regarding the multifarious and novel functions of this family of proteins is examined, with particular attention to their increasing potential in the development, plasticity, and pathology of the CNS. Expand
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