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Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4-5 hours per night.
It is suggested that cumulative nocturnal sleep debt had a dynamic and escalating analog in cumulative daytime sleepiness and that asymptotic or steady-state sleepiness was not achieved in response to sleep restriction.
Rest in Drosophila Is a Sleep-like State
Abnormal sleep/wake cycles and the effect of environmental noise on sleep disruption in the intensive care unit.
- N. Freedman, J. Gazendam, L. Levan, A. Pack, R. Schwab
- Biology, MedicineAmerican journal of respiratory and critical care…
- 30 January 2001
ICU patients are qualitatively, but not necessarily quantitatively, sleep deprived; and although environmental noise is in part responsible for sleep-wake abnormalities, it is not responsible for the majority of the sleep fragmentation and may therefore not be as disruptive to sleep as the previous literature suggests.
An instrument to measure functional status outcomes for disorders of excessive sleepiness.
The FOSQ can be used to determine how disorders of excessive sleepiness affect patients' abilities to conduct normal activities and the extent to which these abilities are improved by effective treatment of DOES.
Upper airway and soft tissue anatomy in normal subjects and patients with sleep-disordered breathing. Significance of the lateral pharyngeal walls.
- R. Schwab, K. B. Gupta, W. Gefter, L. Metzger, E. Hoffman, A. Pack
- MedicineAmerican journal of respiratory and critical care…
- 1 November 1995
The major findings of this investigation in the 68 subjects were that minimum airway area was significantly smaller in apneic compared with normal subjects and occurred in the retropalatal region, and thickness of the lateral pharyngeal muscular walls rather than enlargement of the parapharyngeAL fat pads was the predominant anatomic factor causing airway narrowing in Apneic subjects.
A survey screen for prediction of apnea.
Questionnaire data from patients presenting at three sleep disorders centers were used to develop and assess a screening tool for sleep apnea based on the reporting of the frequency of various…
Objective measurement of patterns of nasal CPAP use by patients with obstructive sleep apnea.
Although the majority (60%) of patients claimed to use CPAP nightly, only 16 of 35 patients met criteria for regular use, defined by at least 4 h of CPAP administered on 70% of the days monitored, and these 16 patients had more years of education, and were more likely to work in professional occupations.
Lethargus is a Caenorhabditis elegans sleep-like state
The association of this C. elegans sleep-like state with developmental changes that occur with larval moults suggests that sleep may have evolved to allow for developmental changes.
Identification of upper airway anatomic risk factors for obstructive sleep apnea with volumetric magnetic resonance imaging.
- R. Schwab, M. Pasirstein, A. Pack
- Medicine, BiologyAmerican journal of respiratory and critical care…
- 1 September 2003
The data support a priori hypotheses that the volume of the soft tissue structures surrounding the upper airway is enlarged in patients withSleep apnea and that this enlargement is a significant risk factor for sleep apnea.
Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning.
Sleep deprivation from 0-5 h after training for this task impaired memory consolidation for contextual fear conditioning whereas sleep deprivation from 5-10H after training had no effect, suggesting that sleep deprivation may act by modifying these molecular mechanisms of memory storage.